W:Ti Flexible Transversal Electrode Array for Peripheral Nerve Stimulation: A Feasibility Study.
W:Ti Flexible Transversal Electrode Array for Peripheral Nerve Stimulation: A Feasibility Study.
复制标题
用于周围神经刺激的 W:Ti 柔性横向电极阵列：可行性研究。
DOI：
10.1109/tnsre.2020.3014812
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Silveira C
中科院分区：
文献类型：
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作者：
Silveira C
神经接口硬件的开发仍然是一个技术挑战。我们介绍了一种灵活的，横向神经内钨：钛电极阵列的急性研究。我们使用循环伏安法和电化学阻抗谱表征这种新的钨和钛的组合的电化学性能。与体内啮齿动物的研究，我们表明，刺激周围神经与此电极阵列是可能的，超过一半的电极接触可以产生0.75或更高的刺激选择性指数在低刺激电流。这项可行性研究为开发未来具有成本效益且易于制造的急性环境神经接口电极铺平了道路，最终可以为开发能够与人类神经系统进行双向通信的技术提供信息。
The development of hardware for neural interfacing remains a technical challenge. We introduce a flexible, transversal intraneural tungsten:titanium electrode array for acute studies. We characterize the electrochemical properties of this new combination of tungsten and titanium using cyclic voltammetry and electrochemical impedance spectroscopy. With an in-vivo rodent study, we show that the stimulation of peripheral nerves with this electrode array is possible and that more than half of the electrode contacts can yield a stimulation selectivity index of 0.75 or higher at low stimulation currents. This feasibility study paves the way for the development of future cost-effective and easy-to-fabricate neural interfacing electrodes for acute settings, which ultimately can inform the development of technologies that enable bi-directional communication with the human nervous system.