Exploring the After-Effects of Theta Burst Magnetic Stimulation on the Human Motor Cortex: A Functional Imaging Study
Exploring the After-Effects of Theta Burst Magnetic Stimulation on the Human Motor Cortex: A Functional Imaging Study
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DOI：
10.1002/hbm.21160
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发表时间：
2011-11-01
影响因子：
4.8
通讯作者：
Kammer, Thomas
中科院分区：
文献类型：
--
作者：
Cardenas-Morales, Lizbeth;Groen, Georg;Kammer, Thomas
Theta burst stimulation（TBS）是一种阈下重复经颅磁刺激（rTMS）方案，可诱导皮层兴奋性的变化。从传统阈下rTMS方案的功能成像研究来看，目前尚不清楚发生了什么类型的调制（方向和对神经活动的依赖性）以及推定的效应是否与脑灌注的非特异性变化有关或需要功能挑战。在一个受试者内（n = 17）重复测量设计，包括真实的TBS和控制会话无刺激，我们研究了神经激活的选择反应任务后，应用间歇性TBS，协议，增强皮质兴奋性的左运动皮层（M1）。通过血氧水平依赖性（BOLD）功能磁共振成像监测脑活动，并使用基于MR的灌注成像测量静息时的局部脑血流量（rCBF）。在另一天，TMS诱导的复合肌肉动作电位（cMAP）振幅的右手兴奋性TBS后进行了测量。与对照组相比，在选择反应任务期间，由于右手运动活动导致的BOLD信号显著减少，主要在刺激后刺激的M1和运动相关的远端区域。这种降低可能代表一种促进效应，因为与对照相比，TBS后cMAP振幅增加。未观察到静息时rCBF变化。数据表明，阈下间歇性TBS的目标是刺激的皮层区域以及远程区域。促进改变神经信号传输的功效似乎反映了BOLD信号的减少，而网络在休息时似乎没有受到影响。《脑地图》32：1948-1960，2011年。(C)2010 Wiley Periodicals，Inc.
Theta burst stimulation (TBS) is a protocol of subthreshold repetitive transcranial magnetic stimulation (rTMS) inducing changes in cortical excitability. From functional imaging studies with conventional subthreshold rTMS protocols, it remains unclear what type of modulation occurs (direction and dependency to neural activity) and whether putative effects are bound to unspecific changes in cerebral perfusion or require a functional challenge. In a within-subjects (n = 17) repeated measurement design including real TBS and a control session without stimulation, we examined neural activation in a choice-reaction task after application of intermittent TBS, a protocol, which enhances cortical excitability over the left motor cortex (M1). Brain activity was monitored by blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging interleaved with measuring regional cerebral blood flow (rCBF) at rest using MR-based perfusion imaging. On a separate day, TMS-induced compound muscle action potentials (cMAPs) amplitude of the right hand was measured after excitatory TBS. Compared to control, a significant decrease in BOLD signal due to right hand motor activity during the choice-reaction task was observed mainly in the stimulated M1 and motor-related remote areas after stimulation. This decrease might represent a facilitating effect, because cMAPs amplitude increased upon TBS compared to control. No changes in rCBF at rest were observed. The data demonstrate that subthreshold intermittent TBS targets both the stimulated cortical area as well as remote areas. The facilitation changing the efficacy of neural signal transmission seems to be reflected by a BOLD signal decrease, whereas the network at rest does not appear to be affected. Hum Brain Mapp 32:1948-1960, 2011. (C) 2010 Wiley Periodicals, Inc.