Balancing Autophagy for a Healthy Heart.
Balancing Autophagy for a Healthy Heart.
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DOI：
10.1016/j.cophys.2017.11.001
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发表时间：
2018-03
影响因子：
2.5
通讯作者：
Gustafsson ÅB
中科院分区：
文献类型：
--
作者：
Lampert MA;Gustafsson ÅB
自噬是一种众所周知的细胞内降解过程，涉及清除细胞中受损或不必要的成分。功能性自噬对于心脏稳态很重要。鉴于此，自噬失调与衰老过程和各种心血管疾病有关也就不足为奇了。因此，了解自噬在各种条件下在心脏中的功能作用以及操纵该途径是否具有治疗益处已成为近年来许多研究的主要焦点。尽管人们一致认为自噬是心脏中关键的细胞质量控制途径，但其在疾病中的作用仍然存在争议。自噬的改变对心脏是保护性的还是有害的似乎取决于环境和疾病。在这里，我们回顾了自噬在心血管稳态和疾病中及其在疾病发展中的作用的最新见解。
Autophagy is a well-known intracellular degradation process involved in clearing damaged or unnecessary components in cells. Functional autophagy is important for cardiac homeostasis. Given this, it is not surprising that dysregulation of autophagy has been implicated in the aging process and in various cardiovascular diseases. Therefore, understanding the functional role of autophagy in the heart under various conditions and whether manipulation of the pathway has therapeutic benefits have been a major focus of many investigations in recent years. Although consensus exists that autophagy is a critical cellular quality control pathway in the heart, its role in disease remains controversial. Whether altered autophagy is protective or detrimental in the heart seems to depend on the context and the disease. Here, we review the latest insights into autophagy in cardiovascular homeostasis and disease and its role in disease development.