Methadyl acetate and methadone as maintenance treatments for heroin addicts. A veterans administration cooperative study.
Methadyl acetate and methadone as maintenance treatments for heroin addicts. A veterans administration cooperative study.
复制标题
醋酸美沙酯和美沙酮作为海洛因成瘾者的维持治疗。
作者：
W. Ling;V. Charuvastra;S. C. Kaim;C. Klett
这是对来自12家退伍军人管理局医院的430名街头海洛因成瘾者使用乙酸甲酯和两种剂量的盐酸美沙酮进行双盲比较。起始样本包括146名接受小剂量美沙酮治疗的患者，142名接受甲基乙酸甲酯治疗的患者。患者首先服用这两种药物30毫克，然后每周递增10毫克，直到他们稳定在醋酸甲酯，每周三次80毫克，以及盐酸美沙酮，每天50毫克或100毫克。其余的40周治疗期的剂量是固定的。安全性通过在整个研究过程中频繁进行的临床和实验室观察进行评估。通过非法药物使用、计划保留率和出勤率以及全球工作人员的判断来评估相对疗效。结论：醋酸美沙酮是一种与美沙酮一样安全的药物，其疗效优于大剂量美沙酮。在本研究的条件下，醋酸甲酯和大剂量美沙酮似乎都是比小剂量美沙酮更好的维持方案。
This was a double-blind comparison of methadyl acetate and two dose levels of methadone hydrochloride in the maintenance of 430 street heroin addicts from 12 Veterans Administration hospitals. The starting sample consisted of 146 patients receiving low-dose methadone, 142 patients receiving methadyl acetate. Patients were first given 30 mg of both drugs, and doses were incremented by 10 mg/week until they stabilized at methadyl acetate, 80 mg three times a week, and methadone hydrochloride, 50 mg daily or 100 mg daily. Dosage was fixed for the balance of the 40-week treatment period. Safety was evaluated by clinical and laboratory observations conducted at frequent intervals throughout the study. Relative efficacy was evaluated by illicit drug use, program retention and attendance, and global staff judgments. It is concluded that methadyl acetate is as safe a drug as methadone and that it compares favorably with highdose methoadone in terms of efficacy. Both methyadyl acetate and high-dose methadone appear to be better maintenance regimens than low-dose methadone under the conditions of this study.