Issues with reducing the rotavirus-associated mortality by vaccination in developing countries
Issues with reducing the rotavirus-associated mortality by vaccination in developing countries
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DOI：
10.1016/j.vaccine.2008.04.004
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发表时间：
2008-06-19
期刊：
影响因子：
5.5
通讯作者：
Nakagomi, Osamu
中科院分区：
文献类型：
--
作者：
Naghipour, Mohammadreza;Nakagomi, Toyoko;Nakagomi, Osamu
据估计，全球65%以上的轮状病毒死亡发生在亚洲和非洲的11个国家，2004年有34.5万5岁以下儿童死亡。虽然有效的轮状病毒疫苗近在眼前，但发现这些国家内部和国家之间卫生服务系统的不平等是实现轮状病毒疫苗目标的主要障碍。如果将目前使用的疫苗的覆盖范围应用于轮状病毒疫苗，最多可避免202,550人死亡。即使覆盖率达到80%，在这11个国家仍有96841名儿童死于轮状病毒腹泻。因此，鼓励研究制定综合战略，以解决卫生服务系统中的不公平现象，从而提高免疫覆盖率。(C) 2008 Elsevier Ltd版权所有。
More than 65% of the global rotavirus deaths were estimated to occur in 11 countries in Asia and Africa, claiming 345,000 children less than 5 years of age in 2004. While efficacious rotavirus vaccines are at hand, inequity in health delivery system within and between these countries was found to be the major hurdle against achieving the goal of rotavirus vaccine. When the coverage of currently used vaccines was applied to a rotavirus vaccine, a maximum of 202,550 deaths would be averted. Even if the coverage reached 80%, there would remain 96,841 children dying because of rotavirus diarrhea in these 11 countries. Studies are therefore encouraged to develop comprehensive strategies to resolve inequity in health delivery system enabling the increase in the immunization coverage. (C) 2008 Elsevier Ltd. All rights reserved.