Enhanced effect of human mesenchymal stem cells expressing human TNF‐αR‐Fc and HO‐1 gene on porcine islet xenotransplantation in humanized mice
Enhanced effect of human mesenchymal stem cells expressing human TNF‐αR‐Fc and HO‐1 gene on porcine islet xenotransplantation in humanized mice
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DOI：
10.1111/xen.12342
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发表时间：
2018
影响因子：
3.9
通讯作者：
Han-Sin Lee;Sanghyun Song;Du Yeon Shin;Geunsoo Kim;Jong-Hyun Lee;C. Cho;Kyo-Won Lee;Hyojun Park-
中科院分区：
文献类型：
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作者：
Han-Sin Lee;Sanghyun Song;Du Yeon Shin;Geunsoo Kim;Jong-Hyun Lee;C. Cho;Kyo-Won Lee;Hyojun Park-
Porcine islet xenotransplantation is considered an attractive alternative treatment for type 1 diabetes mellitus. However, it is largely limited because of initial rejection due to Instant Blood‐Mediated Inflammatory Reaction (IBMIR), oxidative stress, and inflammatory responses. Recently, soluble tumor necrosis factor‐ɑ receptor type I (sTNF‐αR) and heme oxygenase (HO)‐1 genes (HO‐1/sTNF‐αR) have been shown to improve the viability and functionality of porcine islets after transplantation.
