Geographical distribution of the associated factors of osteonecrosis of the femoral head, using the designated intractable disease database in Japan
Geographical distribution of the associated factors of osteonecrosis of the femoral head, using the designated intractable disease database in Japan
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DOI：
10.1093/mr/roab065
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发表时间：
2021-09-10
影响因子：
2.2
通讯作者：
Sugano, Nobuhiko
中科院分区：
文献类型：
--
作者：
Ando, Wataru;Takao, Masaki;Sugano, Nobuhiko
目的股骨头坏死（ONFH）在日本是一种指定顽固性疾病（DID）。厚生劳动省推出了did在线注册系统。我们的目的是利用DID数据库调查ONFH患者的流行病学特征。方法提取2004年1月至2013年12月在DID数据库中登记的ONFH患者资料。调查新发病例的发生率、性别、年龄分布及相关危险因素。估计了每个县“类固醇相关”和“酒精相关”两类风险因素的患病率。结果新增ONFH 15049例。经登记率校正的年平均ONFH发病率为每10万人1.77例。男女比例为1.33。男性的年龄分布在40、50岁，女性的年龄分布在60岁。类固醇相关的ONFH患病率男性（28.6%）低于女性（49.8%），而酒精相关的ONFH患病率男性（47.2%）高于女性（9.3%）。没有明确的类固醇区域。与酒精相关的ONFH发病率在东京和冲绳明显更高，与性别无关。结论：在日本，酒精相关的ONFH发病率在地理上存在差异，这表明它具有区域特征。
Objectives Osteonecrosis of the femoral head (ONFH) is a designated intractable disease (DID) in Japan. The Ministry of Health, Labour, and Welfare launched an online registry system for DIDs. We aimed to investigate the epidemiological characteristics of patients with ONFH using the DID database. Methods Data of patients with ONFH registered in the DID database between January 2004 and December 2013 were extracted. The incidence of new cases and distributions of sex, age, and associated risk factors were investigated. The prevalence of the two categories, 'steroid-associated' and 'alcohol-associated' risk factors, was estimated for each prefecture. Results New 15,049 cases of ONFH were investigated. The mean registration rate-corrected annual ONFH incidence per 100,000 individuals was 1.77. The male-to-female ratio was 1.33. Age distribution peaked in the 40s and 50s for male and 60s for female. The prevalence of steroid-associated ONFH was lower in males (28.6%) than in females (49.8%), while that of alcohol-associated ONFH was higher in males (47.2%) than in females (9.3%). No clear region was identified for the steroids. The incidence of alcohol-associated ONFH was significantly higher in Tokyo and Okinawa, regardless of sex. Conclusions Alcohol-associated ONFH incidence varies geographically across Japan, suggesting that it has regional characteristics.