Applications of proton transfer reaction time-of-flight mass spectrometry for the sensitive and rapid real-time detection of solid high explosives
Applications of proton transfer reaction time-of-flight mass spectrometry for the sensitive and rapid real-time detection of solid high explosives
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DOI：
10.1016/j.ijms.2009.09.006
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发表时间：
2010-01-01
影响因子：
1.8
通讯作者：
Maerk, T. D.
中科院分区：
文献类型：
--
作者：
Mayhew, C. A.;Sulzer, P.;Maerk, T. D.
利用质子转移反应质谱法的最新发展，在这里报告了原理证明调查，以说明实时检测固体炸药的能力。本研究使用了两台质子转移反应飞行时间质谱仪（Ionicon Analytik）。一种具有增强的质量分辨率（m/Delta m高达8000）和高灵敏度（类似于50 cps/ppbv）。第二种增强了灵敏度（类似于250 cps/ppbv），同时仍然保持高分辨率能力（m/Delta m高达2000）。这两种仪器都已成功地用于识别固体炸药（RDX， TNT， HMX， PETN和Semtex A），通过分析室温下少量样品上方的顶空和肉眼看不到的痕量放置在表面上。对于痕量测量，设计并使用了一种简单的预浓缩和热解吸技术。重要的是，我们证明了在复杂的化学环境中明确识别威胁因子，其中有多种威胁因子和干扰物；可能存在，从而消除假阳性。这对安全和打击恐怖主义有相当大的好处。(C) 2009 Elsevier B.V.版权所有
Using recent developments in proton transfer reaction mass spectrometry, proof-of-principle investigations are reported here to illustrate the capabilities of detecting solid explosives in real-time. Two proton transfer reaction time-of-flight mass spectrometers (Ionicon Analytik) have been used in this study. One has an enhanced mass resolution (m/Delta m up to 8000) and high sensitivity (similar to 50 cps/ppbv). The second has enhanced sensitivity (similar to 250 cps/ppbv) whilst still retaining high resolution capabilities (m/Delta m up to 2000). Both of these instruments have been successfully used to identify solid explosives (RDX, TNT, HMX, PETN and Semtex A) by analyzing the headspace above small quantities of samples at room temperature and from trace quantities not visible to the naked eye placed on surfaces. For the trace measurements a simple pre-concentration and thermal desorption technique was devised and used. Importantly, we demonstrate the unambiguous identification of threat agents in complex chemical environments, where multiple threat agents and interferents; may be present, thereby eliminating false positives. This is of considerable benefit to security and for the fight against terrorism. (C) 2009 Elsevier B.V. All rights reserved.