The primate working memory networks
The primate working memory networks
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DOI：
10.3758/cabn.4.4.444
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发表时间：
2004-12-04
影响因子：
2.9
通讯作者：
Procyk, Emmanuel
中科院分区：
文献类型：
--
作者：
Constantinidis, Christos;Procyk, Emmanuel
长期以来，人们一直将工作记忆与前额叶皮层联系在一起，因为这一大脑区域的损伤会严重损害维持和更新记忆信息的能力。然而，解剖学和生理学的证据表明，前额叶皮层是与工作记忆有关的更广泛的相互关联的大脑区域网络的一部分。这些区域包括大脑皮层的顶叶和颞叶关联区、扣带区和边缘区，以及皮层下结构，如丘脑中背侧和基底神经节。对灵长类动物的神经生理学研究证实，工作记忆涉及额叶以外的区域，并说明工作记忆涉及平行的、分布式的神经网络。在这篇文章中，我们回顾了目前对调节工作记忆的网络的解剖组织的理解，以及在它们的每个节点中表现出来的记忆的神经关联。对记忆维持的神经机制和前额叶皮层的综合作用也进行了讨论。
Working memory has long been associated with the prefrontal cortex, since damage to this brain area can critically impair the ability to maintain and update mnemonic information. Anatomical and physiological evidence suggests, however, that the prefrontal cortex is part of a broader network of interconnected brain areas involved in working memory. These include the parietal and temporal association areas of the cerebral cortex, cingulate and limbic areas, and subcortical structures such as the mediodorsal thalamus and the basal ganglia. Neurophysiological studies in primates confirm the involvement of areas beyond the frontal lobe and illustrate that working memory involves parallel, distributed neuronal networks. In this article, we review the current understanding of the anatomical organization of networks mediating working memory and the neural correlates of memory manifested in each of their nodes. The neural mechanisms of memory maintenance and the integrative role of the prefrontal cortex are also discussed.