Inclusion of fish or fish oil in weight-loss diets for young adults:: effects on blood lipids
Inclusion of fish or fish oil in weight-loss diets for young adults:: effects on blood lipids
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DOI：
10.1038/ijo.2008.64
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发表时间：
2008-07-01
影响因子：
4.9
通讯作者：
Thorsdottir, I.
中科院分区：
文献类型：
--
作者：
Gunnarsdottir, I.;Tomasson, H.;Thorsdottir, I.
目的：为了评估鱼（瘦或油）和鱼油消费对血脂浓度的影响，在weight loss.Design：随机，控制8周的试验，能量限制饮食不同的鱼和鱼油含量。来自冰岛、西班牙和爱尔兰的324名男性和女性受试者，年龄20-40岁，体重指数27.5-32.5 kg/m（-2），被随机分为四组：（1）对照（向日葵籽油胶囊，无海鲜），（2）鳕鱼饮食（3 x 150 g周（-1）），（3）鲑鱼饮食（3 x 150 g周（-1）），（4）鱼油（DHA/EPA胶囊，无海鲜）。两组之间的膳食常量营养素组成相似，胶囊组是单盲的。测量：在基线和终点测量总胆固醇（TC）、高密度脂蛋白（HDL）和低密度脂蛋白胆固醇、三酰甘油（TG）和人体测量学。对照组和鳕鱼饮食之间logTG降低的差异，鲑鱼饮食和鱼油从基线到终点的差异分别为-0.036（95% CI -0.079至0.006）、-0.060（-0.101至0.018）和-0.037（-0.079至0.006）。鱼组（鳕鱼和鲑鱼）中TC的降低比对照组高出约0.2 mmol l（-1），但在调整体重减轻时仅具有边缘意义。高密度脂蛋白倾向于减少饮食组消耗大量的n-3脂肪酸（鲑鱼和鱼油）。结论：减肥饮食，包括油性鱼导致更大的TG降低比没有鱼或鱼油的饮食。鼓励使用整条鱼作为试验餐的对照试验，以便能够阐明鱼的不同成分对人类健康的作用。
Objective: To assess the effects of fish (lean or oily) and fish oil consumption on blood lipid concentration during weight loss.Design: Randomized, controlled 8-week trial of energy-restricted diet varying in fish and fish oil content. Subjects, 324 men and women, aged 20-40 years, body mass index 27.5-32.5 kg m(-2), from Iceland, Spain and Ireland, were randomized to one of four groups: (1) control (sunflower oil capsules, no seafood), (2) cod diet (3 x 150 g week(-1)), (3) salmon diet (3 x 150 g week(-1)), (4) fish oil (DHA/EPA capsules, no seafood). The macronutrient composition of the diets was similar between the groups and the capsule groups were single-blinded.Measurements: Total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein cholesterol, triacylglycerol (TG) and anthropometrics were measured at baseline and end point.Results: The difference in logTG lowering between the control group and the cod diet, salmon diet and fish oil from baseline to end point was -0.036 (95% CI -0.079 to 0.006), -0.060 (-0.101 to -0.018) and -0.037 (-0.079 to 0.006), respectively. Reduction in TC was about 0.2 mmol l(-1) greater in the fish groups (cod and salmon) than in the control group, but only of borderline significance when adjusting for weight loss. HDL tended to decrease less in the diet groups consuming a significant amount of n-3 fatty acids (salmon and fish oil).Conclusion: Weight-loss diet including oily fish resulted in greater TG reduction than did a diet without fish or fish oil. Controlled trials using whole fish as a test meal are encouraged to be able to elucidate the role of different constituents of fish for human health.