ISOLATION AND STRUCTURE ELUCIDATION OF RITTERAZINE-B AND RITTERAZINE-C, HIGHLY CYTOTOXIC DIMERIC STEROIDAL ALKALOIDS, FROM THE TUNICATE RITTERELLA-TOKIOKA
ISOLATION AND STRUCTURE ELUCIDATION OF RITTERAZINE-B AND RITTERAZINE-C, HIGHLY CYTOTOXIC DIMERIC STEROIDAL ALKALOIDS, FROM THE TUNICATE RITTERELLA-TOKIOKA
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DOI：
10.1021/jo00108a024
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发表时间：
1995-02-10
影响因子：
3.6
通讯作者：
FUSETANI, N
中科院分区：
文献类型：
--
作者：
FUKUZAWA, S;MATSUNAGA, S;FUSETANI, N
利特拉嗪B和C是从被囊动物Ritterella tokioka中分离得到的与头孢菌素类化合物有关的二聚体甾体生物碱。利特拉嗪B和C对P388小鼠白血病细胞显示出强效细胞毒性，IC 50分别为0.018和9.4 ng/mL。
Ritterazines B and C, dimeric steroidal alkaloids related to the cephalostatins, have been isolated from the tunicate Ritterella tokioka and their structures including absolute stereochemistry have been elucidated by spectral and chemical methods. Ritterazines B and C showed potent cytotoxicity against the P388 murine leukemia cells with IC50's of 0.018 and 9.4 ng/mL, respectively.