Eculizumab treatment for renal failure in a pediatric patient with COVID-19.

Eculizumab treatment for renal failure in a pediatric patient with COVID-19.
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DOI:
10.1007/s40620-020-00858-2
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发表时间:
2020-12
影响因子:
3.4
通讯作者:
Uy NS
Uy NS
中科院分区:
医学3区
文献类型:
--
作者:
Mahajan R;Lipton M;Broglie L;Jain NG;Uy NS

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虽然住院的成人COVID-19患者中出现急性肾损伤的报告越来越多,但关于儿童与COVID-19相关的肾脏并发症的信息仍然有限。COVID-19肾脏受累的原因可能是多因素的,似乎涉及一个复杂的过程,包括补体失调和血栓性微血管病变。我们报告了一例小儿COVID-19合并肾衰竭,由于thombotic微血管病变,成功地用eculizumab治疗。
While there are increasing reports of acute kidney injury among hospitalized adults with COVID-19, there is still limited information on renal complications associated with COVID-19 in children. The cause of kidney involvement in COVID-19 is likely multifactorial, and appears to involve a complex process, including complement dysregulation and thrombotic microangiopathy. We present a pediatric case of COVID-19 and renal failure due to thombotic microangiopathy, successfully treated with eculizumab.
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