Force from cat soleus muscle during imposed locomotor-like movements: Experimental data versus hill-type model predictions
Force from cat soleus muscle during imposed locomotor-like movements: Experimental data versus hill-type model predictions
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DOI：
10.1152/jn.1997.77.3.1538
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发表时间：
1997-03-01
影响因子：
2.5
通讯作者：
Heckman, CJ
中科院分区：
文献类型：
--
作者：
Sandercock, TG;Heckman, CJ
肌肉通常在非生理条件下进行研究，如强直刺激或等速运动，这些条件是为了分离肌肉的特定特性或机制而选择的。本研究的目的是测量猫比目鱼肌在生理条件下的功能，特别是模拟单一速度的慢走，以确定所产生的力是否可以用hill型模型准确地表示。由于hill型模型不包括历史依赖的肌肉特性或特性之间的相互作用，因此预测力的误差大小有望揭示这些现象是否在这种运动模式的生理条件中发挥重要作用。从文献中获得慢走时的自然运动长度模式和慢走时低阈运动单元的动作电位训练。运动脉冲序列同步刺激整个比目鱼肌，同时肌肉牵拉器施加运动运动。实验结果与自由行走动物通过扣式传感器测得的力相似。采用Hill-type模型模拟运动力。在另一组实验中。hill型模型所需的参数（力-速度、长度-张力和系列弹性元件的刚度）是在同一块肌肉上测量的。激活是通过使用相同运动刺激模式的等距收缩的逆计算来确定的。在刺激训练过程中，hill型模型对运动数据拟合较好，但存在误差
Muscle is usually studied under nonphysiological conditions, such as tetanic stimulation or isovelocity movements, conditions selected to isolate specific properties or mechanisms in muscle. The purpose of this study was to measure the function of cat soleus muscle during physiological conditions, specifically a simulation of a single speed of slow walking, to determine whether the resulting force could be accurately represented by a Hill-type model. Because Hill-type models do not include history-dependent muscle properties or interactions among properties,the magnitudes of errors in predicted forces were expected to reveal whether these phenomena play important roles in the physiological conditions of this locomotor pattern. The natural locomotor length pattern during slow walking, and the action potential train for a low-threshold motor unit during slow walking, were obtained from the literature. The whole soleus muscle was synchronously stimulated with the locomotor pulse train while a muscle puller imposed the locomotor movement. The experimental results were similar to force measured via buckle transducer in freely walking animals. A Hill-type model was used to simulate the locomotor force. In a separate set of experiments. the parameters needed for a Hill-type model (force-velocity, length-tension, and stiffness of the series elastic element) were measured from the same muscle. Activation was determined by inverse computation of an isometric contraction with the use of the same locomotor stimulus pattern. During the stimulus train, the Hill-type model fit the locomotor data fairly well, with errors