LAMINATES COMPOSED OF POLYPEPTIDES AND ELASTOMERS AS A BURN WOUND COVERING - PHYSICOCHEMICAL PROPERTIES
LAMINATES COMPOSED OF POLYPEPTIDES AND ELASTOMERS AS A BURN WOUND COVERING - PHYSICOCHEMICAL PROPERTIES
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DOI：
10.1016/0142-9612(85)90084-5
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发表时间：
1985-01-01
期刊：
影响因子：
14
通讯作者：
NAKAGAWA, T
中科院分区：
文献类型：
--
作者：
AIBA, S;MINOURA, N;NAKAGAWA, T
合成多肽和弹性体层压材料已被制备、表征和评价其作为烧伤创面覆盖物的应用。研究发现，含L蛋氨酸(Met)的多肽膜被过氧化氢氧化后，其水蒸气透过率(WVtr‘’S)增大。弹性体膜具有较高的粘度，S和良好的拉伸性能，用于伤口覆盖。含氧化蛋氨酸的共聚肽和聚氨酯组成的层压板具有高的WVTR值‘’S(790-1050g.cntdo.M-2.cntdo.第一天)；例如，由氧化的蛋氨酸和含有共聚肽的N-苄氧甲酰基-L-赖氨酸和聚氨酯组成的层压板具有高的WVTR值(960g.cntdo.M-.cntdo.D-1)和较大的延伸率(556%)，而且即使在高压灭菌后，该层压板的两层之间的粘结力也一样强。这些特性似乎对层压板在伤口覆盖中的可能应用非常有吸引力。此外，还讨论了无线录像机的测量方法。
Laminates of synthetic polypeptides and elastomers, have been prepared, characterized and evaluated in terms of their application as a burn wound covering. It was found that the oxidation of L-methionine(Met)-containing polypeptide films by hydrogen peroxide led to an increase in the water vapour transmission rates (WVTR''s) of the films. Elastomeric films had high WVTR''s and good tensile properties for wound covering. The laminates composed of oxidized Met-containing copolypeptides and polyurethane had high WVTR''s (790-1050 g .cntdot. m-2 .cntdot. day-1); for example, the laminate composed of an oxidized Met and N.epsilon.-benzyloxycarbonyl-L-lysine containing copolypeptide and polyurethane had high WVTR(960 g .cntdot. m- .cntdot. d-1) and large elongation (556%), also the cohesion between the two layers of this laminate as strong even after autoclaving. These characteristics seem to be very attractive for the possible application of laminates to wound covering. In addition the method of measuring WVTR is discussed.