Mortality differences between men and women after percutaneous coronary interventions
Mortality differences between men and women after percutaneous coronary interventions
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DOI：
10.1016/j.jacc.2008.01.066
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发表时间：
2008-06-17
影响因子：
24
通讯作者：
Holmes, David R., Jr.
中科院分区：
文献类型：
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作者：
Singh, Mandeep;Rihal, Charanjit S.;Holmes, David R., Jr.
目的：我们的目的是研究在过去25年中，经皮冠状动脉介入治疗（PCI）后死亡率的性别差异是否发生了变化。背景：女性冠心病患者PCI后不良结局的风险高于男性。最近的时间趋势，在短期和长期的死亡率在妇女后PCIS.Methods我们进行了一项回顾性队列研究18,885连续，独特的患者接受PCI之间1979年和1995年（早期组，n = 7,904，28%的妇女）和1996年和2004年（最近组，n = 10,981，31%的妇女）。30天和长期的死亡率进行了比较，性别。结果与男性相比，女性接受PCI年龄较大，更容易有糖尿病，高血压，或高胆固醇血症。总体而言，PCI在89%的女性和90%的男性中成功。在近期组中，与早期组相比，女性（2.9% vs. 4.4%，p = 0.002）和男性（2.2% vs. 2.8%，p = 0.04）的30天死亡率显著降低。然而，男性和女性的早期和近期组之间的长期生存率相似。调整后的风险因素，有没有男性和女性之间的差异，从1994年起，无论是30天或长期outcome.Conclusions男性和女性PCI后的30天死亡率在过去的25年中有所下降。在考虑基线风险后，男性和女性之间的短期或长期死亡率没有差异。
Objectives Our aim was to examine whether gender-based differences in mortality after percutaneous coronary interventions (PCIs) have changed in the past 25 years.Background Women with coronary artery disease have a higher risk of adverse outcomes after PCIs than do men. Recent temporal trends in short-term and long-term mortality in women after PCIs are unknown.Methods We performed a retrospective cohort study of 18,885 consecutive, unique patients who underwent PCIs between 1979 and 1995 (early group, n = 7,904, 28% women) and between 1996 and 2004 (recent group, n = 10,981, 31% women). Thirty-day and long-term mortality were compared by gender.Results Compared with men, women undergoing PCIs were older and more likely to have diabetes mellitus, hypertension, or hypercholesterolemia. Overall, PCI was successful in 89% of women and 90% of men. In the recent group, 30-day mortality was significantly reduced compared with that in the early group in women (2.9% vs. 4.4%, p = 0.002) and men (2.2% vs. 2.8%, p = 0.04). However, long-term survival was similar between the early and recent groups among both men and women. After adjustment for risk factors, there was no difference between men and women from 1994 onward for either 30-day or long-term outcomes.Conclusions The 30-day mortality after PCI in men and women has decreased in the past 25 years. After accounting for baseline risks, no differences in short-term or long-term mortality were observed between men and women.