The effects of slice-selective excitation/refocusing in localized spectral editing with gradient-selected double-quantum coherence transfer
The effects of slice-selective excitation/refocusing in localized spectral editing with gradient-selected double-quantum coherence transfer
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DOI：
10.1006/jmre.2001.2304
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发表时间：
2001-05-01
影响因子：
2.2
通讯作者：
Dunn, J
中科院分区：
文献类型：
--
作者：
Lei, H;Dunn, J
采用梯度选择双量子滤波(DQF)和压力定位的光谱编辑技术已被用于体内代谢产物的选择性观察。在以前使用局部化DQF序列的研究中，通常假设序列中使用的切片选择性脉冲在相干传输中没有作用，并且不干扰DQE。为了验证这一假设，在结合新闻定位的DQF乳酸编辑序列中，研究了切片选择性激发/重聚焦对DQF的影响。与前面的假设相反，结果表明，由于化学位移伪影和J耦合，DQF中的切片选择确实会干扰相干传递，从而对空间定位的精度和检测灵敏度产生不利影响。在乳酸编辑的情况下，这种干扰的影响可以简单地通过调整切片选择梯度的强度和通过使用窄带切片选择性重新聚焦脉冲来解释。(C)2001年学术出版社。
Spectral editing using gradient-selected double-quantum filtering (DQF) with PRESS localization has been used for selective observation of metabolites in vivo. In previous studies using localized DQF sequences, it is generally assumed that the slice-selective pulses used in the sequence have no roles in coherence transfer, and do not interfere with DQE. To validate this assumption, the effects of slice-selective excitation/refocusing on DQF were investigated in DQF lactate editing sequences combined with PRESS localization. Contrary to the previous assumption, the results show that, due to chemical shift displacement artifact and J coupling, slice selection in DQF does interfere with coherence transfer, affecting both the accuracy of spatial localization and the detection sensitivity adversely. In the case of lactate editing, the effects of this interference can be accounted for simply by adjusting the strength of the slice-selection gradients and by using narrowband slice-selective refocusing pulses. (C) 2001 Academic Press.