Preparation of stretchable composite film and its application in skin burn repair
Preparation of stretchable composite film and its application in skin burn repair
复制标题
DOI：
10.1016/j.jmbbm.2020.104114
复制
发表时间：
2021-01-01
影响因子：
3.9
通讯作者：
Wang, Jin-Ye
中科院分区：
文献类型：
--
作者：
Wang, Li-Ping;Wang, Hua-Jie;Wang, Jin-Ye
创面敷料弹性差，常因断裂、脱落等原因导致创面愈合失败。为获得皮肤烧伤修复用可伸缩创面敷料，研制了玉米醇溶蛋白与水凝胶聚丙烯酸复合膜。力学性能测试表明，玉米醇溶蛋白与聚丙烯酸质量比为1.5时，复合膜的断裂伸长率最大可达349.76%。扫描电子显微镜和傅里叶变换红外光谱分析表明，复合膜具有良好的弹性可能是由于复合膜中玉米醇溶蛋白与聚丙烯酸之间形成了致密的结构和较强的相互作用所致。有趣的是，复合膜对人体手指皮肤具有良好的粘附性，并在剧烈关节运动下具有伸展能力。CCK-8检测和荧光染色结果表明，复合膜及其提取物对人包皮成纤维细胞(L929)具有良好的细胞相容性。大鼠皮肤烧伤模型的体内实验表明，与商品纱布相比，复合膜具有促进创面愈合和胶原合成的作用。由此可见，玉米醇溶蛋白与水凝胶聚丙烯酸可伸缩复合膜具有作为创面敷料的潜力。
The poor elasticity of wound dressings often leads to wound healing failure due to rupture and fall off. In this study, the composite films of zein and hydrogel poly (acrylic acid) were developed in order to obtain stretchable wound dressing for skin burn repair. The mechanical test revealed that the maximum elongation of break of composite films could reach 349.76% when the mass ratio of zein to poly (acrylic acid) was 1.5. SEM and FTIR analysis demonstrated the good elasticity of composite films might be due to the formation of a dense structure and the strong interaction between zein and poly (acrylic acid). Interestingly, the composite films exhibited great adhesiveness to human finger skin and stretchable ability under strenuous joint exercise. CCK-8 assay and fluorescence staining showed that the composite films and their extract had good cytocompatibility on human foreskin fibroblasts (L929) cells. The in vivo experiment on rat's skin burning model indicated that the composite films could promote wound healing and collagen synthesis by comparison with commercial gauze. It could be concluded that the stretchable composite films of zein and hydrogel poly (acrylic acid) had the potential as the wound dressing.