Comparing self-perceived and estimated fracture risk by FRAX® of women with osteoporosis
Comparing self-perceived and estimated fracture risk by FRAX® of women with osteoporosis
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DOI：
10.1007/s11657-016-0300-5
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发表时间：
2017-12-01
影响因子：
3
通讯作者：
Pentek, Marta
中科院分区：
文献类型：
--
作者：
Baji, Petra;Gulacsi, Laszlo;Pentek, Marta
在这项研究中，我们比较了匈牙利妇女骨质疏松症的主观骨折风险FRAX（R）为基础的估计。有骨折史、父母髋部骨折、股骨T评分低、年龄大、BMI高的患者更容易低估其风险。患者也未能将风险因素与骨折风险增加联系起来。目的主要目的是探讨骨质疏松症（OP）妇女自我感知的10年骨折风险与FRAX（R）算法计算的风险之间的关系，并确定风险低估的决定因素。在匈牙利的11个OP中心进行了一项横断面研究，并收集了FRAX（R）计算器考虑的风险因素的数据。患者用数字、百分比和视觉模拟量表（VAS）评估其主观10年内发生任何严重腰椎骨折和髋部骨折的概率。我们比较了主观估计和FRAX（R）估计，并应用逻辑回归分析了低估风险的决定因素。采用线性概率模型探讨了各种危险因素与主观危险度之间的关系。FRAX（R）的主要OP和髋部骨折风险平均为20.1%和10.5%，而主观估计值分别为30.0%和24.7%。FRAX（R）与主观测量之间的相关性非常弱（r = 0.12-0.16）。严重OP骨折风险的低估与既往单一骨折（OR = 2.0）、父母髋部骨折（OR = 3.4）、股骨T评分
In this study, we compared subjective fracture risks of Hungarian women with osteoporosis to FRAX (R)-based estimates. Patients with a previous fracture, parental hip fracture, low femoral T-score, higher age, and higher BMI were more likely to underestimate their risks. Patients also failed to associate risk factors with an increased risk of fractures.Purpose The main objectives were to explore associations between self-perceived 10-year fracture risks of women with osteoporosis (OP) and their risks calculated by the FRAX (R) algorithm and to identify determinants of the underestimation of risk.Methods We carried out a cross-sectional study in 11 OP centers in Hungary and collected data on the risk factors considered by the FRAX (R)-calculator. Patients estimated their subjective 10-year probability of any major osteoporotic and hip fracture numerically, in percentages and also on a visual analog scale (VAS). We compared subjective and FRAX (R) estimates and applied logistic regression to analyze the determinants of the underestimation of risk. Associations between risk factors and subjective risk were explored using linear probability models.Results Nine hundred seventy-two OP patients were included in the analysis. Major OP and hip fracture risk by FRAX (R) were on average 20.1 and 10.5%, while subjective estimates were significantly higher, 30.0 and 24.7%, respectively. Correlations between FRAX (R) and subjective measures were very weak (r = 0.12-0.16). Underestimation of major OP fracture risk was associated with having had a single previous fracture (OR = 2.0), parental hip fracture (OR = 3.4), femoral T-score