Concentration-Dependent Inhibitory Effect of Irbesartan on Renal Uric Acid Transporters
Concentration-Dependent Inhibitory Effect of Irbesartan on Renal Uric Acid Transporters
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DOI：
10.1254/jphs.10064sc
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发表时间：
2010-09-01
影响因子：
3.5
通讯作者：
Ichida, Kimiyoshi
中科院分区：
文献类型：
--
作者：
Nakamura, Makiko;Anzai, Naohiko;Ichida, Kimiyoshi
高尿酸血症是目前公认的心血管疾病的危险因素。据报道，血管紧张素II受体阻滞剂（ARB）氯沙坦可降低血清尿酸水平。在这项研究中，另一种ARB，厄贝沙坦，对[C-14]尿酸转运活性的肾尿酸重吸收转运蛋白URAT 1和URATV 1的影响进行了检查与爪蟾卵母细胞表达每个转运蛋白。结果表明，厄贝沙坦（100 - 500 μ M）通过两种转运蛋白抑制尿酸的摄取。厄贝沙坦的抑制作用优于氯沙坦和其他ARB，结果表明厄贝沙坦可降低血清尿酸水平。
Hyperuricemia is currently recognized as a risk factor for cardiovascular diseases. It has been reported that the angiotensin II-receptor blocker (ARB) losartan decreases serum uric acid level. In this study, the effects of another ARB, irbesartan, on [C-14]uric acid-transport activity of renal uric acid reabsorptive transporters URAT1 and URATV1 were examined with Xenopus oocytes expressing each transporter. The results showed that irbesartan (100 - 500 mu M) inhibited the uptake of uric acid via both transporters. The inhibitory effects of irbesartan exceeded those of losartan and other ARBs, and the results suggest that irbesartan can reduce serum uric acid level.