N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor.
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor.
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N-乙酰天冬氨酰谷氨酸：一种与大脑“谷氨酸”受体具有高亲和力的内源性肽。
DOI：
10.1073/pnas.80.4.1116
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发表时间：
1983
影响因子：
11.1
通讯作者：
Joseph T. Coyle
中科院分区：
文献类型：
--
作者：
R. Zaczek;Kerry Koller;Robert J. Cotter;David J. Heller;Joseph T. Coyle
已鉴定出一种对L-[3 H]谷氨酸标记的脑受体位点具有高亲和力（420 nM）和显著特异性的脑肽。氨基酸分析和质谱分析表明该肽为N-乙酰基谷氨酸。当注射到大鼠海马体中时，这种肽表现出强有力的惊厥特性，类似于谷氨酸受体激动剂使君子酸产生的惊厥特性。这些发现提出了一个问题，即富含酸性氨基酸的内源性脑肽是否可以作为兴奋性神经递质。
A brain peptide with high affinity (420 nM) and marked specificity for brain receptor sites labeled with L-[3H]glutamate has been identified. Amino acid analysis and mass spectroscopy indicate that the peptide is N-acetylaspartylglutamate. The peptide exhibits potent convulsant properties when injected into the rat hippocampus, similar to those produced by the glutamate receptor agonist, quisqualic acid. These findings raise the question whether endogenous brain peptides enriched in acidic amino acids may serve as excitatory neurotransmitters.