Physical Activity, Sedentary Behavior, and Inflammatory and Hemostatic Markers in Men.
Physical Activity, Sedentary Behavior, and Inflammatory and Hemostatic Markers in Men.
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DOI：
10.1249/mss.0000000000001113
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发表时间：
2017-03
影响因子：
4.1
通讯作者：
Jefferis BJ
中科院分区：
文献类型：
--
作者：
Parsons TJ;Sartini C;Welsh P;Sattar N;Ash S;Lennon LT;Wannamethee SG;Lee IM;Whincup PH;Jefferis BJ
确定老年男性中较高水平的体力活动（PA）和较少的久坐行为（SB）是否与炎症和止血生物标志物指示的炎症较少相关。来自英国区域心脏研究的1139名男性的横断面研究，年龄78（5）（平均值（SD））y和490名男性的纵向分析，两次PA测量间隔1年。分析单个空腹静脉血样品的几种生物标志物。使用Actigraph GT 3X加速度计测量PA和SB。总时间，以及在中度到剧烈的体力活动（MVPA），轻体力活动和SB的发作所花费的时间。线性回归分析被用来调查协会。横断面上，较高的总PA、每日步数和MVPA均与较低水平的白细胞介素6（IL-6）、C反应蛋白（CRP）、组织纤溶酶原激活物（tPA）、血管性血友病因子（vWF）和D-二聚体相关，而较高水平的SB与较高水平的IL-6、CRP和tPA相关。MVPA每增加10分钟与IL-6降低3.2%相关（95% CI-4.5，-1.8%），CRP降低5.6%（95% CI-7.8，-3.3），tPA降低2.2%（95% CI-3.0，-1.4），vWF降低1.2% SB与IL-6或tPA的相关性与MVPA无关。较长的PA或SB发作与结局的相关性并不强于较短的发作。纵向分析与这些结果不一致，可能是由于功率限制。虽然PA（特别是MVPA）通常与炎症和止血生物标志物相关，但我们没有发现证据表明较长的发作比较短的发作更重要。
To determine whether higher levels of physical activity (PA) and less sedentary behavior (SB) are associated with less inflammation, indicated by inflammatory and hemostatic biomarkers, in older men. Cross-sectional study of 1139 men, from the British Regional Heart Study, age 78 (5) (mean (SD) y and longitudinal analyses of 490 men with two PA measures 1 year apart. Single fasting venous blood samples were analyzed for several biomarkers. PA and SB were measured using Actigraph GT3X accelerometers. Total time, and time spent in bouts of moderate to vigorous physical activity (MVPA), light physical activity and SB were derived. Linear regression analyses were used to investigate associations. Cross-sectionally, higher total PA, daily steps, and MVPA were all associated with lower levels of interleukin 6 (IL-6), C-reactive protein (CRP), tissue plasminogen activator (tPA), von Willebrand factor (vWF), and D-Dimer, whilst higher levels of SB were associated with higher levels of IL-6, CRP and tPA. Each additional 10 minutes of MVPA was associated with a 3.2% lower IL-6 (95% CI -4.5, -1.8%), 5.6% lower CRP (95% CI -7.8, -3.3), 2.2% lower tPA (95% CI -3.0, -1.4), 1.2% lower vWF (95% CI -2.1, -0.3) and 1.8% lower D-dimer (95% CI -2.9, 0.7), and for CRP, vWF and D-dimer independently of SB. Associations between SB and IL-6 or tPA were independent of MVPA. Longer bouts of PA or SB were not more strongly associated with outcomes than shorter bouts. Longitudinal analyses were inconsistent with these findings, possibly due to power limitations. Although PA (particularly MVPA) was generally associated with inflammatory and hemostatic biomarkers, we found no evidence that longer bouts were more important than shorter bouts.