Drosophila odz gene is required for multiple cell types in the compound retina
Drosophila odz gene is required for multiple cell types in the compound retina
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DOI：
10.1002/dvdy.21284
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发表时间：
2007-09-01
影响因子：
2.5
通讯作者：
Wides, Ron
中科院分区：
文献类型：
--
作者：
Kinel-Tahan, Yael;Weiss, Hanna;Wides, Ron
黑腹果蝇配对规则基因odz（odd Oz，或Ten-m）在幼虫的眼睛成虫盘中以不同的模式表达。其最早的眼睛表达发生在小眼前体中，从形态发生沟的后缘开始。odz活性功能的丧失导致可见光光感受器丧失; R7感受器丧失;小眼大小、形状和旋转缺陷;小眼紊乱和融合;小眼间刚毛缺陷;和小眼透镜缺陷。在odz眼有丝分裂克隆、od-Ten-alpha transhetozygous组合和表达Odz显性阴性转基因（Odz-DN）的眼中观察到相同的效应。当Odz-DN转基因仅在粗糙表达区域驱动时，也可以看到相同强度的效果，该区域与犁沟后面的四列Odz表达簇重叠。小的odz有丝分裂克隆表明odz在细胞增殖或存活中的作用。无意义的表达在odz突变克隆，在一个相当有序的方式，表明Odz的行为下游的R8规范。在odz克隆中每个小眼内的紊乱伴随着R7前体和可见光感受器前体顺序的一些损失。
The Drosophila melanogaster pair-rule gene odz (odd Oz, or Ten-m) is expressed in distinct patterns in the larval eye imaginal disc. Its earliest eye expression occurs in ommatidial precursors starting from the posterior edge of the morphogenetic furrow. Loss of function of odz activity leads to visible light photoreceptor loss; R7 photoreceptor loss; ommatidial size, shape, and rotation defects; ommatidial disorder and fusions; interommatidial bristle defects; and ommatidial lens defects. The same effects are seen in odz eye mitotic clones, in od-Ten-alpha transheterozygous combinations, and in eyes expressing an Odz-Dominant Negative transgene (Odz-DN). Effects of the same strength are also seen when the Odz-DN transgene is driven only in regions of scabrous expression, which overlaps the four columns of Odz expression clusters behind the furrow. Small odz mitotic clones suggest an odz role in cell proliferation or survival. Senseless is expressed in odz mutant clones, in a fairly ordered manner, indicating that Odz acts downstream of R8 specification. Disorder within each ommatidium in odz clones is accompanied by some loss of R7 precursors and visible photoreceptor precursor order.