Tuftsin: a hormone-like tetrapeptide with antimicrobial and antitumor activities.
Tuftsin: a hormone-like tetrapeptide with antimicrobial and antitumor activities.
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Tuftsin：一种激素样四肽，具有抗菌和抗肿瘤活性。
DOI：
10.1016/0024-3205(81)90684-6
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发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
Babcock,GF
中科院分区：
文献类型：
--
作者：
Nishioka,K;Amoscato,AA;Babcock,GF
免疫球蛋白G的一个特定部分与多形核中性粒细胞结合并刺激其吞噬活性。这种吞噬刺激活性仅存在于一种称为tuftsin的小肽中，其序列为Thr-Lys-Pro-Arg，它已从嗜白细胞免疫球蛋白G组分中分离出来。在脾切除患者和先天性tuftsin异常的患者中已经证明了tuftsin的生理意义，其中血清中tuftsin的低水平（通过放射免疫测定法可测量）与感染的高发病率一致。除吞噬作用外，Tuftsin还显示出增强杀菌活性。其生物活性似乎是通过巨噬细胞、单核细胞和粒细胞上发现的特异性tuftsin受体介导的。此外，tuftsin对白细胞具有趋化性、迁移增强和促有丝分裂特性，并且最近已显示出增强它们的体外以及体内抗肿瘤活性。tuftsin的其他已知活性包括对己糖单磷酸分流的活性、对细胞内环核苷酸浓度和对白细胞中Ca 2+流出的影响。Tuftsin已经在各种实验室中使用不同的程序化学合成，并且也可商购获得。tuftsin的上述特征加上该肽预期的低毒性使tuftsin成为一种非常有吸引力的抗感染和癌症免疫治疗剂。然而，由于某些商业制剂中发现了抑制性污染物，因此在使用簇蛋白时需要非常谨慎。
A specific fraction of immunoglobulin G binds to polymorphonuclear neutrophils and stimulates their phagocytic activity. This phagocytosis-stimulating activity resides solely in a small peptide termed tuftsin, of the sequence Thr-Lys-Pro-Arg, which has been isolated from the leukophilic immunoglobulin G fraction. The physiological significance of tuftsin has been demonstrated in splenectomized patients and patients with a congenital tuftsin abnormality, in whom the low levels of tuftsin in sera (measurable by radioimmunoassay) coincides with a high incidence of infection. Tuftsin has also been shown to enhance bactericidal activity in addition to phagocytosis. Its biological activities appear to be mediated via specific tuftsin receptors which have been found on macrophages, monocytes and granulocytes. In addition, tuftsin possesses chemotactic, migration-enhancing and mitogenic properties for leukocytes and has recently been shown to enhance their anti-tumor activity in vitro as well as in vivo. Other known activities of tuftsin include effects on the activity of the hexose monophosphate shunt, on the concentrations of intracellular cyclic nucleotides and on the efflux of Ca 2+ in leukocytes. Tuftsin has been chemically synthesized in various laboratories using different procedures and also is available commercially. The above features of tuftsin plus the expected low toxicity of this peptide make tuftsin a very attractive agent for immunotherapy against infection and cancer. However, a great deal of caution needs to be exercised when using tuftsin due to inhibitory contaminants found in certain commercial preparations.