PET-CT: accuracy of PET and CT spatial registration of lung lesions
PET-CT: accuracy of PET and CT spatial registration of lung lesions
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DOI：
10.1007/s00259-002-1055-3
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发表时间：
2003-05-01
影响因子：
9.1
通讯作者：
Wahl, RL
中科院分区：
文献类型：
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作者：
Cohade, C;Osman, M;Wahl, RL
PET-CT扫描仪提供独特的能力，通过快速全身配准获取PET和CT数据。本研究的目的是评估18F-2-脱氧-D-葡萄糖(FDG)阳性肺部病变患者的PET和CT数据空间配准的准确性。对244例接受全身FDG PET-CT成像(GE Discovery LS、CT衰减校正、OSEM重建)的临床患者的PET、CT和融合后的PET-CT图像进行了评价。这项分析的纳入标准是PET和CT都清楚显示的肺部病变，病变直径小于5厘米，边界清晰。在PET和CT图像采集期间，患者被允许自由呼吸。对于PET和CT图像，分别确定病变视觉估计中心的空间坐标，并进行比较。36例患者(女性26例，男性10例)共48个病灶(其中肺癌19例26个病灶，肺转移17例22个病灶)。病变直径平均为15.6±9 mm。PET和CT独立确定的病变中心之间的平均距离为7.55+/-4.73 mm。下肺(10.2±-6.55 mm)较上肺(6.67±-4.28 mm)的配准错误更明显(P=0.063)。左肺(8.33±-5.05 mm)比右肺(6.25±3.92 mm)的配准错误也更明显(P=0.059)。总之，使用专用的PET-CT扫描仪和这种临床实用的成像算法，配准通常是准确的，但也会发生原发肺部病变的空间配准错误。
PET-CT scanners offer the unique ability to acquire PET and CT data with rapid full body registration. The purpose of this study was to evaluate the accuracy of spatial registration between PET and CT data in patients with fluorine-18 fluoro-2-deoxy-D-glucose (FDG)-avid lung lesions. PET, CT and fused PET-CT images from 244 consecutive clinical patients undergoing whole-body FDG PET-CT imaging (GE Discovery LS, CT attenuation correction, OSEM reconstruction) were evaluated. Inclusion criteria for this analysis were lung lesions clearly defined on both PET and CT, lesion diameter less than 5 cm and clear borders. Patients were allowed to breathe freely during both PET and CT image acquisitions. The spatial coordinates of the visually estimated centers of the lesion were determined independently for PET and CT images and compared. Thirty-six patients (26 females, 10 males) with a total of 48 lesions were included (19 lung cancer patients with 26 lesions, 17 patients with 22 lung metastases). The average lung lesion diameter was 15.6 +/- 9 mm. The mean-distance between the center of lesions independently determined for both PET and CT was 7.55 +/- 4.73 mm. Misregistration tended to be more pronounced in the lower lungs (10.2 +/- 6.55 mm) than in the upper lungs (6.67 +/- 4.28 mm) (P=0.063). Misregistration also tended to be slightly more pronounced in the left lung (8.33 +/- 5.05 mm) than in the right lung (6.25 +/- 3.92 mm) (P=0.059). In conclusion, with a dedicated PET-CT scanner and this clinically practical imaging algorithm, registration is usually accurate, but spatial misregistration of primary lung lesions does occur.