SEROTYPE DISTRIBUTION OF STREPTOCOCCUS-PNEUMONIAE INFECTIONS AMONG PRESCHOOL-CHILDREN IN THE UNITED-STATES, 1978-1994 - IMPLICATIONS FOR DEVELOPMENT OF A CONJUGATE VACCINE
SEROTYPE DISTRIBUTION OF STREPTOCOCCUS-PNEUMONIAE INFECTIONS AMONG PRESCHOOL-CHILDREN IN THE UNITED-STATES, 1978-1994 - IMPLICATIONS FOR DEVELOPMENT OF A CONJUGATE VACCINE
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DOI：
10.1093/infdis/171.4.885
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发表时间：
1995-04-01
影响因子：
6.4
通讯作者：
FACKLAM, RR
中科院分区：
文献类型：
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作者：
BUTLER, JC;BREIMAN, RF;FACKLAM, RR
肺炎球菌多糖抗原与蛋白质载体的结合可以提高幼儿接种后的保护性免疫力，幼儿是肺炎链球菌感染发病率高且对多糖疫苗免疫应答差的年龄组。为了确定最常与幼儿感染相关的血清型，对3884名儿童的肺炎球菌分离株进行了血清型分析
Conjugation of pneumococcal polysaccharide antigens to a protein carrier may improve protective immunity after vaccination of young children, an age group with high incidence of Streptococcus pneumoniae infection and poor immune responses to polysaccharide vaccines. To identify serotypes most commonly associated with infection in young children, pneumococcal isolates were serotyped from 3884 children