On the antioxidant mechanism of curcumin: Classical methods are needed to determine antioxidant mechanism and activity
On the antioxidant mechanism of curcumin: Classical methods are needed to determine antioxidant mechanism and activity
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DOI：
10.1021/ol000173t
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发表时间：
2000-09-07
期刊：
影响因子：
5.2
通讯作者：
Uno, H
中科院分区：
文献类型：
--
作者：
Barclay, LRC;Vinqvist, MR;Uno, H
姜黄素（1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮）的抗氧化活性是通过抑制苯乙烯氧化的受控引发来测定的，合成的非酚类姜黄素没有表现出抗氧化活性；因此，姜黄素是一种经典的酚类断链抗氧化剂，它从酚基团而不是 CH2 基团中提供 H 原子（Jovanovic et at. J. Am. Chem, Sec. 1999, 121, 9677）。微米级甲氧基苯酚的抗氧化活性在接受氢键的介质中降低。
The antioxidant activity of curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) was determined by inhibition of controlled initiation of styrene oxidation, Synthetic nonphenolic curcuminoids exhibited no antioxidant activity; therefore, curcumin is a classical phenolic chain-breaking antioxidant, donating H atoms from the phenolic groups not the CH2 group as has been suggested (Jovanovic et at. J. Am. Chem, Sec. 1999, 121, 9677). The antioxidant activities of omicron-methoxyphenols are decreased in hydrogen bond accepting media.