Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation
Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation
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DOI：
10.1359/jbmr.040205
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发表时间：
2004-06-01
影响因子：
6.2
通讯作者：
Schett, G
中科院分区：
文献类型：
--
作者：
Görtz, B;Hayer, S;Schett, G
关节炎可破坏骨皮质屏障，使骨髓暴露于滑膜组织。本研究检测了关节炎时骨髓的变化及其对皮质骨重建的影响。关节炎病灶旁骨髓表现为富含B淋巴细胞的浸润，其表达BMP并刺激骨内膜骨形成。因此，骨髓积极参与关节炎的过程。
Arthritis can destroy the cortical bone barrier and expose bone marrow to synovial tissue. This study examines bone marrow changes in arthritis and its effects on cortical bone remodeling. Bone marrow next to arthritic lesions exhibits B-lymphocyte-rich infiltrates, which express BMPs and stimulate endosteal bone formation. Thus, bone marrow actively participates in the arthritic process.