PROGNOSIS OF PATIENTS WITH UNILATERAL RENAL AGENESIS
PROGNOSIS OF PATIENTS WITH UNILATERAL RENAL AGENESIS
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DOI：
10.1007/bf00873996
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发表时间：
1992-09-01
影响因子：
3
通讯作者：
KRAMER, SA
中科院分区：
文献类型：
--
作者：
ARGUESO, LR;RITCHEY, ML;KRAMER, SA
我们回顾了157例单侧肾发育不全和对侧肾正常的患者的临床过程，以确定预后。男性85人（54%），女性72人（46%）。诊断单侧肾发育不全的平均年龄为37岁。平均风险年数为56年。在37名受试患者中，19%的患者发现蛋白尿（> 150 mg/24 h）（P < 0.001），47名受试患者中47%的患者发生高血压（P = 0.010），32名受试患者中13%的患者肾功能（经年龄和性别调整）下降（P = 0.001）。在评价的13例患者中，7例（54%）发现滤过分数增加。在这项研究完成时，114名患者（73%）存活，存活率与年龄、性别匹配的美国生命表相似。43例患者（27%）死亡; 6例死亡（4%）由肾衰竭引起。我们的综述表明，单侧肾发育不全和正常孤立肾的患者发生蛋白尿、高血压和肾功能不全的风险增加。因此，必须进行长期和仔细的随访，并采用最大限度地保护肾脏的策略。
The clinical course was reviewed in 157 patients with unilateral renal agenesis and a normal contralateral kidney for the purpose of establishing a prognosis. There were 85 males (54%) and 72 females (46%). The mean age at diagnosis of unilateral renal agenesis was 37 years. The mean years at risk was 56. Proteinuria (> 150 mg/24 h) was found in 19% of the 37 patients tested (P < 0.001), hypertension developed in 47% of the 47 patients tested (P = 0.010), and renal function (adjusted for age and sex) was decreased in 13% of the 32 patients tested (P = 0.001). An increased filtration fraction was found in 7 (54%) of 13 patients evaluated. At the completion of this study, 114 patients (73%) were alive, and the survival rate was similar to that of age-, sex-matched United States life tables. Forty-three patients (27%) died; 6 deaths (4%) were caused by renal failure. Our review indicates that patients with unilateral renal agenesis and a normal solitary kidney are at increased risk of proteinuria, hypertension, and renal insufficiency. Therefore, it is essential to have prolonged and careful follow-up and to employ strategies that maximize renal preservation.