Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population.
Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population.
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DOI：
10.1016/j.jpsychires.2008.01.013
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发表时间：
2008-11
影响因子：
4.8
通讯作者：
Shusuke Numata;S. Ueno;Jun‐ichi Iga;Hongwei Song;Masahito Nakataki;Shin'ya Tayoshi;Satsuki Sumitani;M. Tomotake;M. Itakura;A. Sano;T. Ohmori
中科院分区：
文献类型：
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作者：
Shusuke Numata;S. Ueno;Jun‐ichi Iga;Hongwei Song;Masahito Nakataki;Shin'ya Tayoshi;Satsuki Sumitani;M. Tomotake;M. Itakura;A. Sano;T. Ohmori
磷酸二酯酶 4B (PDE4B) 基因位于 1p31，这是精神分裂症 (SZ) 的易感区域。此外，PDE4B 与 DISC1 相互作用，DISC1 是 SZ 的已知遗传风险因素。最近，有报道称 PDE4B 基因与白种人和非裔美国人群体中的 SZ 相关。在这项研究中，在日本人群中进行了病例对照关联分析，以确定 PDE4B 基因是否与 SZ 有关。对 444 名精神分裂症患者和 452 名对照受试者的 13 个单核苷酸多态性 (SNP) 进行了分析。应用多重检验校正后，三个 SNP（rs2180335、rs910694 和 rs472952）与 SZ 显着相关（p=0.039、0.004 和 0.028）。此外，还发现特定单倍型（rs2180335 和 rs910694）与 SZ 之间存在显着关联（排列 p=0.001）。我们的结果表明 PDE4B 基因座的变异可能在日本人群 SZ 的病因学中发挥重要作用。
The phosphodiesterase 4B (PDE4B) gene is located at 1p31, a susceptibility region for schizophrenia (SZ). Moreover, PDE4B interacts with DISC1, which is a known genetic risk factor for SZ. Recently, it was reported that the PDE4B gene is associated with SZ in Caucasian and African American populations. In this study, case-controlled association analyses were performed in the Japanese population to determine if the PDE4B gene is implicated in SZ. Thirteen single nucleotide polymorphisms (SNPs) were analyzed in 444 schizophrenic patients and 452 control subjects. Three SNPs (rs2180335, rs910694 and rs472952) were significantly associated with SZ after applying multiple test correction (p=0.039, 0.004 and 0.028). In addition, a significant association was found between specific haplotypes (rs2180335 and rs910694) and SZ (permutation p=0.001). Our result suggests that variations at the PDE4B locus may play a significant role in the etiology of SZ in the Japanese population.