The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature
The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature
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DOI：
10.1016/j.psyneuen.2006.01.005
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发表时间：
2006-07-01
影响因子：
3.7
通讯作者：
Harris, Alan
中科院分区：
文献类型：
--
作者：
Falleti, Marina G.;Maruff, Paul;Harris, Alan
目的：神经心理学文献中越来越多的证据表明生长激素（GH）缺乏与认知功能障碍有关。也有证据表明，这种损害可能会改善生长激素替代治疗。本研究通过对迄今为止发表的文献进行荟萃分析，评估了生长激素缺乏相关的认知功能障碍的性质和严重程度，以及生长激素替代对认知功能的影响。8例（8例前瞻性，其中2例还包括横断面比较）研究GH替代。计算了6个认知领域的效应量（Cohen's d）（分别用于GH缺乏和GH替代）。结果：与匹配的对照组相比，GH缺乏时，评估的每个认知领域（除语言外）均显示出中度至重度损害（效应量-0.46至-1.46）。对于生长激素替代品，即使治疗的患者仍然进行中度大大低于对照组，当与自己的基线相比（如在前瞻性分析），中度改善被发现在认知性能，特别是注意力和memory.Conclusion：这项荟萃分析清楚地表明生长激素和认知性能之间的联系，在性能差，可以改善生长激素治疗。(c)2006爱思唯尔有限公司保留所有权利。
Objective: There is growing evidence in the neuropsychological literature that growth hormone (GH) deficiency is associated with cognitive impairment. There is also evidence that this impairment may be ameliorated with GH replacement therapy. The current study assessed the nature and severity of cognitive impairment associated with growth hormone deficiency, as well as effect of GH replacement on cognitive function by conducting a-meta-analysis of the published literature to date.Method: Thirteen studies met the inclusion criteria and these included: five cross-sectional studies investigating GH deficiency; and, eight (eight prospective, two of which also included cross-sectional comparisons) investigating GH replacement. Effect sizes (Cohen's d) fatting into six cognitive domains were computed (separately for GH deficiency and GH replacement).Results: For GH deficiency, each of the cognitive domains assessed (besides language) showed moderate to Large impairments when compared to matched controls (Effect sizes -0.46 to - 1.46). For GH replacement, even though treated patients still performed moderately to largely below that of controls, when compared to their own baselines (as in prospective analyses), moderate improvements were found in cognitive performance, particularly attention and memory.Conclusion: This meta-analysis clearly demonstrates the link between GH and cognitive performance, where poor performance can be ameliorated with GH treatment. (c) 2006 Elsevier Ltd. All rights reserved.