Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial.
Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial.
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DOI：
10.1158/0008-5472.can-11-3092
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发表时间：
2012-05-01
期刊：
影响因子：
11.2
通讯作者：
McTiernan A
中科院分区：
文献类型：
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作者：
Imayama I;Ulrich CM;Alfano CM;Wang C;Xiao L;Wener MH;Campbell KL;Duggan C;Foster-Schubert KE;Kong A;Mason CE;Wang CY;Blackburn GL;Bain CE;Thompson HJ;McTiernan A
肥胖和久坐的人患癌症的风险增加;炎症是一种假设的机制。我们在439名女性中研究了热量限制、减肥饮食和运动对炎症生物标志物的影响。超重和肥胖的绝经后妇女被随机分配到1年：热量限制饮食（目标是体重减轻10%，N=118），有氧运动（225分钟/周的中度至剧烈活动，N=117），饮食+运动（N=117）或对照（N=87）。由研究者在不知情的情况下测量基线和1年的超敏C反应蛋白（hs-CRP）、血清淀粉样蛋白A（SAA）、白细胞介素-6（IL-6）、白细胞和中性粒细胞水平。使用广义估计方程比较炎症生物标志物的变化。根据基线体重指数（BMI）、人种/种族和年龄调整模型。共分析438例（排除饮食+运动组N=1例）。与对照组相比，饮食组hs-CRP降低了0.92 mg/L（0.53-1.31，P<0.001），饮食+运动组hs-CRP降低了0.87 mg/L（0.51-1.23，P<0.0001）。IL-6在饮食组降低0.34pg/ml（0.13-0.55，P=0.001），在饮食+运动组降低0.32pg/ml（0.15-0.49，P<0.001）。饮食组和饮食+运动组的神经细胞计数分别降低了0.31×109/L（0.09-0.54，P=0.006）和0.30×109/L（0.09-0.50，P=0.005）。与对照组相比，体重减轻≥5%的饮食和饮食+运动参与者减少了炎症生物标志物（hs-CRP、SAA和IL-6）。饮食组和饮食+运动组在基线BMI、腰围、CRP水平和空腹血糖的所有亚组中均降低了hs-CRP。我们的研究结果表明，热量限制减肥饮食结合或不结合运动可以减少绝经后妇女的炎症生物标志物，对降低癌症风险具有潜在的临床意义。
Obese and sedentary persons have increased risk for cancer; inflammation is a hypothesized mechanism. We examined the effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in 439 women. Overweight and obese postmenopausal women were randomized to 1-year: caloric restriction diet (goal of 10% weight loss, N=118), aerobic exercise (225 minutes/week of moderate-to-vigorous activity, N=117), combined diet+exercise (N=117) or control (N=87). Baseline and 1-year high-sensitivity C-reactive protein (hs-CRP), serum amyloid A (SAA), interleukin-6 (IL-6), leukocyte and neutrophil levels were measured by investigators blind to group. Inflammatory biomarker changes were compared using generalized estimating equations. Models were adjusted for baseline body mass index (BMI), race/ethnicity and age. 438 (N=1 in diet+exercise group was excluded) were analyzed. Relative to controls, hs-CRP decreased by geometric mean (95% confidence interval, p-value) 0.92mg/L (0.53–1.31, P<0.001) in the diet and 0.87mg/L (0.51–1.23, P<0.0001) in the diet+exercise groups. IL-6 decreased by 0.34pg/ml (0.13–0.55, P=0.001) in the diet and 0.32pg/ml (0.15–0.49, P<0.001) in the diet+exercise groups. Neutrophil counts decreased by 0.31×109/L (0.09–0.54, P=0.006) in the diet and 0.30×109/L (0.09–0.50, P=0.005) in the diet+exercise groups. Diet and diet+exercise participants with ≥5% weight loss reduced inflammatory biomarkers (hs-CRP, SAA, and IL-6) compared to controls. The diet and diet+exercise groups reduced hs-CRP in all subgroups of baseline BMI, waist circumference, CRP level, and fasting glucose. Our findings indicate that a caloric restriction weight loss diet with or without exercise reduces biomarkers of inflammation in postmenopausal women, with potential clinical significance for cancer risk reduction.