Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence
Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence
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DOI：
10.1093/brain/awg216
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发表时间：
2003-10-01
期刊：
影响因子：
14.5
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Critchley, HD;Mathias, CJ;Dolan, RJ
人类前扣带回功能主要在认知框架内解释。我们使用功能性MRI实验与同步心电图检查区域大脑活动与自主心血管控制在认知和运动任务的性能。使用心率变异性指数，以及心脏节律中的高频和低频功率，我们观察到背侧前扣带皮层（ACC）中与心率交感神经调制相关的活动，该活动与认知和运动相关活动无关。研究结果预测，在努力的认知和运动行为的背侧ACC支持相关的自主状态的心血管觉醒的产生。随后，我们通过研究三名涉及ACC的局灶性损伤患者来测试这一预测，同时他们进行了努力的认知和运动测试。与147名以相同方式测试的正常受试者相比，每个人都表现出自主心血管反应的异常，对精神压力的自主觉醒减弱。因此，汇聚神经影像学和临床研究结果表明，ACC功能介导的身体唤醒状态的上下文驱动的调制。
Human anterior cingulate function has been explained primarily within a cognitive framework. We used functional MRI experiments with simultaneous electrocardiography to examine regional brain activity associated with autonomic cardiovascular control during performance of cognitive and motor tasks. Using indices of heart rate variability, and high- and low-frequency power in the cardiac rhythm, we observed activity in the dorsal anterior cingulate cortex (ACC) related to sympathetic modulation of heart rate that was dissociable from cognitive and motor-related activity. The findings predict that during effortful cognitive and motor behaviour the dorsal ACC supports the generation of associated autonomic states of cardiovascular arousal. We subsequently tested this prediction by studying three patients with focal damage involving the ACC while they performed effortful cognitive and motor tests. Each showed abnormalities in autonomic cardiovascular responses with blunted autonomic arousal to mental stress when compared with 147 normal subjects tested in identical fashion. Thus, converging neuroimaging and clinical findings suggest that ACC function mediates context-driven modulation of bodily arousal states.