Chromatin as a potential carrier of heritable information.
Chromatin as a potential carrier of heritable information.
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DOI：
10.1016/j.ceb.2010.02.002
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发表时间：
2010-06
影响因子：
7.5
通讯作者：
Rando OJ
中科院分区：
文献类型：
--
作者：
Kaufman PD;Rando OJ
具有相同基因组的生物体可以继承DNA序列中编码的信息之外的信息-这被称为表观遗传遗传。表观遗传是多细胞生物中不同细胞类型之间的许多表型差异的原因。在过去的几十年里，许多研究人员的工作表明，大量的表观遗传信息可能携带在组蛋白的翻译后修饰模式中，尽管这并不像许多人认为的那样确定。例如，目前还不清楚组蛋白是否以及如何将信息从一个细胞世代传递到下一个细胞世代，组蛋白在复制叉通过时从染色体上移位，并且通常在其他时间从DNA模板交换。在这里，我们简要回顾了一些染色质状态确实是可遗传的证据，然后专注于仍然存在的机械挑战，以了解如何实现这种遗传。
Organisms with the same genome can inherit information in addition to that encoded in the DNA sequence — this is known as epigenetic inheritance. Epigenetic inheritance is responsible for many of the phenotypic differences between different cell types in multicellular organisms. Work by many investigators over the past decades has suggested that a great deal of epigenetic information might be carried in the pattern of post-translational modifications of the histone proteins, although this is not as well established as many believe. For example, it is unclear whether and how the histones, which are displaced from the chromosome during passage of the replication fork and are often exchanged from the DNA template at other times, carry information from one cellular generation to the next. Here, we briefly review the evidence that some chromatin states are indeed heritable, and then focus on the mechanistic challenges that remain in order to understand how this inheritance can be achieved.
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影响因子：
9.8
作者：
Brickner DG;Cajigas I;Fondufe-Mittendorf Y;Ahmed S;Lee PC;Widom J;Brickner JH
通讯作者：
Brickner JH
影响因子：
10.5
作者：
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Pradhan, Sriharsa
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TILGHMAN, SM
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作者：
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通讯作者：
Helin, Kristian
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作者：
Carmen, AA;Milne, L;Grunstein, M
通讯作者：
Grunstein, M