Transdermal drug delivery.
Transdermal drug delivery.
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DOI：
10.1038/nbt.1504
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发表时间：
2008-11
影响因子：
46.9
通讯作者：
Langer, Robert
中科院分区：
文献类型：
--
作者：
Prausnitz, Mark R.;Langer, Robert
经皮给药对医疗实践做出了重要贡献，但作为口服给药和皮下注射的替代品，其潜力尚未完全实现。第一代经皮给药系统在临床上用于递送小的、亲脂性的、低剂量的药物方面的应用持续稳定增长。使用化学增强剂、非空化超声和离子电渗疗法的第二代递送系统也已经产生了临床产品;离子电渗疗法在真实的时间内控制递送速率的能力提供了附加的功能。第三代递送系统使用微针、热消融、微晶磨皮术、电穿孔和空化超声将其作用靶向皮肤的角质层屏障层。针和热消融目前正在通过临床试验进展，用于递送大分子和疫苗，如胰岛素、甲状旁腺激素和流感疫苗。使用这些新的第二代和第三代增强策略，透皮给药有望显着增加对医学的影响。
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability of iontophoresis to control delivery rates in real time provides added functionality. Third-generation delivery systems target their effects to skin’s barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound. Microneedles and thermal ablation are currently progressing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase impact on medicine.
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影响因子：
46.9
作者：
Karande, P;Jain, A;Mitragotri, S
通讯作者：
Mitragotri, S
通过噬菌体展示鉴定的共同施用的肽进行透皮蛋白质递送
影响因子：
46.9
作者：
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通讯作者：
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2.4
作者：
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通讯作者：
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影响因子：
10.8
作者：
Kim, Yeu-Chun;Ludovice, Peter J.;Prausnitz, Mark R.
通讯作者：
Prausnitz, Mark R.
影响因子：
5.8
作者：
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通讯作者：
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