Four million newborn deaths: Is the global research agenda evidence-based?
Four million newborn deaths: Is the global research agenda evidence-based?
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DOI：
10.1016/j.earlhumdev.2008.09.009
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发表时间：
2008-12-01
影响因子：
2.5
通讯作者：
Rubens, Craig
中科院分区：
文献类型：
--
作者：
Lawn, Joy E.;Rudan, Igor;Rubens, Craig
每年有四百万新生儿死亡。这些死亡大多发生在低收入国家，但新生儿死亡率和发病率也是高收入国家的一个优先负担。流行病学证据表明，新生儿研究将优先考虑最贫困的家庭：出生和生命的最初几天;主要原因，特别是感染，早产和窒息;并包括预防战略以及改善护理。然而，研究投资与负担不相称，与当前的研究优先事项不匹配。南亚和撒哈拉以南非洲。美国承担了75%的负担，每年花费约2000万美元用于新生儿研究，这只是富裕国家用于较小比例健康问题的一小部分。我们提出了一个描述，发现，开发解决方案和提供研究的研究管道，并扩大规模，以达到最贫困的家庭。列出研究选项并应用定量评分可以实现系统、透明的研究优先顺序排列。除了研究管道之外，还需要“人员管道”，以在低收入国家产生研究能力。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Four million neonates die each year. These deaths are mostly in low-income countries, but neonatal mortality and morbidity are also a priority burden in high-income countries. Epidemiological evidence suggests newborn research would prioritise the poorest families: birth and the first days of life; major causes particularly infections, preterm birth and asphyxia: and include preventive strategies as well as improved care. However research investment is not commensurate to burden, and there is a mismatch with current research priorities. South Asia and sub Saharan Africa. with 75% of the burden, expend around US$20 million per year on newborn research, a fraction of what is spent on a smaller proportion of health problem in rich countries. We propose a research pipeline of description, discovery, development of solutions and delivery of research with scale-up to reach the poorest families. Listing research options and applying quantitative scoring enables systematic, transparent research prioritisation. As well as a research pipeline, a "people pipeline" is required to generate research capacity in low-income countries. (C) 2008 Elsevier Ireland Ltd. All rights reserved.