IMPLICATIONS OF THE PRESENCE OF AN INTERNAL IMAGE OF THE ANTIGEN IN ANTI-IDIOTYPIC ANTIBODIES - POSSIBLE APPLICATION TO VACCINE PRODUCTION
IMPLICATIONS OF THE PRESENCE OF AN INTERNAL IMAGE OF THE ANTIGEN IN ANTI-IDIOTYPIC ANTIBODIES - POSSIBLE APPLICATION TO VACCINE PRODUCTION
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DOI：
10.1016/0090-1229(81)90228-2
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
LAMOYI, E
中科院分区：
文献类型：
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作者：
NISONOFF, A;LAMOYI, E
现在有强有力的证据提示，一些抗独特型抗体可能具有与原始抗原(抗原X)上的表位(S)密切相关的>；1抗原决定簇(表位)。因此，一些抗X的分子可能与X共享一个表位。当这种情况发生时，来自不同来源的抗X抗体之间会发生广泛的独特型交叉反应，如果X是一种激素，交叉反应可能包括该激素的细胞表面受体。这种交叉反应可能导致对观察到的交叉反应独特型的遗传意义的误解。对这一现象的证据及其可能与某些涉及细胞表面受体的自身免疫性疾病过程的关系进行了综述。讨论了获得抗独特型单抗的可能性，其表位类似于感染剂上的表位。这种单抗在接种时可能会产生保护性抗体，从而起到疫苗的作用。
There is now strong suggestive evidence that some anti-idiotypic antibodies may possess > 1 antigen determinants (epitopes) that are closely related to epitope(s) on the original antigen (antigen X). Thus, some molecules of anti-anti X may share an epitope with X. When this occurs a wide range of idiotypic cross-reactions will be observed among anti-X antibodies from various sources and, if X is a hormone, the cross-reactions may include cell surface receptors for the hormone. Such cross-reactions can lead to misinterpretation of the genetic significance of the observed cross-reactive idiotypy. The evidence for this phenomenon and its possible relationship to certain autoimmune disease processes involving cell surface receptors were reviewed. The possibility is discussed of obtaining monoclonal anti-idiotypic antibodies with epitopes similar to those on an infectious agent. Such a monoclonal antibody might elicit protective antibodies when inoculated and thus, act as a vaccine.