Virological and clinical implication of core promoter C1752/V1753 and T1764/G1766 mutations in hepatitis B virus genotype D infection in Mongolia
Virological and clinical implication of core promoter C1752/V1753 and T1764/G1766 mutations in hepatitis B virus genotype D infection in Mongolia
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DOI：
10.1111/j.1440-1746.2008.05321.x
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发表时间：
2008-03-01
影响因子：
4.1
通讯作者：
Mizokami, Masashi
中科院分区：
文献类型：
--
作者：
Elkady, Abeer;Tanaka, Yasuhito;Mizokami, Masashi
背景与目的：本研究旨在揭示D型肝炎病毒感染的病毒学和临床特征。方法：对122例蒙古族慢性肝病患者进行血清乙肝标志物筛查和酶免疫分型。对48株HBVD型毒株(23株来自肝细胞癌，25株来自慢性肝病患者)进行了核苷酸序列分析。结果：年轻患者中乙肝e抗原(HBeAg)阳性率较低(25.9%)(=5对数拷贝/毫升)。70.8%的患者检测到前C区终止密码子突变A1896。结论：在蒙古族感染者中，C1752和/或V1753突变与肝细胞癌的发生有关。
Background and Aim: The aim of the present study was to reveal virological and clinical features of hepatitis B virus (HBV) genotype D infection.Methods: One hundred and twenty-two Mongolian chronic liver disease (CLD) patients infected with HBV were subjected for serological HBV-markers screening and HBV-enzyme immunoassay (EIA) genotyping. Nucleotide sequences were analyzed for 48 HBV/D strains (23 isolated from hepatocellular carcinoma (HCC) and 25 from CLD patients).Results: Prevalence of hepatitis B e antigen (HBeAg) positivity was low (25.9%) in young patients (= 5 log copies/mL). Precore stop codon mutation A1896 was detected in (70.8%) of HBV/D-infected patients.Conclusions: In Mongolians infected with HBV/D, C1752 and/or V1753 mutation was associated with HCC.