Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection
Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection
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DOI：
10.1086/427239
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发表时间：
2005-02-15
影响因子：
6.4
通讯作者：
Morishima, T
中科院分区：
文献类型：
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作者：
Kimura, H;Hoshino, Y;Morishima, T
T细胞和自然杀伤（NK）细胞的感染在慢性活动性EB病毒（CAEBV）感染的发病机制中起着核心作用。为了表征T细胞型和NK细胞型感染的病毒学和细胞因子谱，分析了39例CAEBV感染患者。T细胞型感染的患者对早期和晚期EBV抗原的免疫球蛋白G滴度较高，表明裂解周期感染。然而，EB病毒基因表达的模式是潜伏II型; BZLF 1，这是一个标志性的裂解周期感染，不能在任何患者中检测到，无论感染类型。CAEBV感染的患者具有高浓度的促炎性、T辅助细胞1型和抗炎性细胞因子。NK细胞型感染患者的细胞因子谱与T细胞型感染患者相似，但NK细胞型感染患者的IL-13浓度较高。这些发现有助于阐明CAEBV感染的发病机制，并促进更有效的治疗方法的发展。
Infections of T cells and natural killer (NK) cells play a central role in the pathogenesis of chronic active Epstein-Barr virus (CAEBV) infection. To characterize the virologic and cytokine profiles of T cell-type and NK cell-type infection, 39 patients with CAEBV infection were analyzed. Patients with T cell-type infection had higher titers of immunoglobulin G against early and late EBV antigens, suggesting lytic cycle infection. However, the pattern of EBV gene expression was latency type II; BZLF1, which is a hallmark of lytic cycle infection, could not be detected in any patients, regardless of infection type. Patients with CAEBV infection had high concentrations of proinflammatory, T helper cell type 1, and anti-inflammatory cytokines. The cytokine profile in patients with NK cell-type infection was similar to that in patients with T cell-type infection, but the concentration of IL-13 was high in patients with NK cell-type infection. These findings should help to clarify the pathogenesis of CAEBV infection and facilitate the development of more-effective treatments.