A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain
A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain
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DOI：
10.1542/peds.2010-0467
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发表时间：
2010-12-01
期刊：
影响因子：
8
通讯作者：
Cavallo, Luciano
中科院分区：
文献类型：
--
作者：
Francavilla, Ruggiero;Miniello, Vito;Cavallo, Luciano
目的：我们的目的是确定是否鼠李糖乳杆菌GG（LGG）缓解症状的儿童复发性abdominal pain.Patients和方法：共141名儿童肠易激综合征（IBS）或功能性疼痛，参加了9个初级保健网站和转诊中心。儿童进入一项随机、双盲、安慰剂对照试验，接受LGG或安慰剂8周，并进入8周随访。主要结局是干预期结束时的总体疼痛。在试验开始和结束时，儿童进行了双糖肠通透性试验。结果：与基线相比，LGG，而不是安慰剂，引起腹痛的频率（P <0.01）和严重程度（P <0.01）显着降低。这些差异在随访结束时仍然具有显著性（分别为P <0.02和P <0.001）。在第12周，LGG组有48名儿童获得治疗成功，而安慰剂组有37名儿童获得治疗成功（P < .03）;这种差异在随访结束时仍然存在（P < .03）。在入组时，59%的儿童肠道通透性试验结果异常; LGG，而不是安慰剂，确定了肠道通透性试验结果异常的患者数量显着减少（P <0.03）。这些影响主要是在儿童IBS。结论：LGG显着降低频率和严重程度的腹痛儿童IBS，这种效果是持续的，可能是次要的肠道屏障的改善。儿科2010;126：e1445-e1452
OBJECTIVE: Our aim was to determine whether Lactobacillus rhamnosus GG (LGG) relieves symptoms in children with recurrent abdominal pain.PATIENTS AND METHODS: A total of 141 children with irritable bowel syndrome (IBS) or functional pain were enrolled in 9 primary care sites and a referral center. Children entered a randomized, double-blind, placebo-controlled trial and received LGG or placebo for 8 weeks and entered follow-up for 8 weeks. The primary outcome was overall pain at the end of the intervention period. At entry and at the end of the trial, children underwent a double-sugar intestinal permeability test.RESULTS: Compared with baseline, LGG, but not placebo, caused a significant reduction of both frequency (P < .01) and severity (P < .01) of abdominal pain. These differences still were significant at the end of follow-up (P < .02 and P < .001, respectively). At week 12, treatment success was achieved in 48 children in the LGG group compared with 37 children in the placebo group (P < .03); this difference still was present at the end of follow-up (P < .03). At entry, 59% of the children had abnormal results from the intestinal permeability test; LGG, but not placebo, determined a significant decrease in the number of patients with abnormal results from the intestinal permeability testing (P < .03). These effects mainly were in children with IBS.CONCLUSIONS: LGG significantly reduces the frequency and severity of abdominal pain in children with IBS; this effect is sustained and may be secondary to improvement of the gut barrier. Pediatrics 2010;126:e1445-e1452