The clinical and immunomodulatory effects of green soybean extracts
The clinical and immunomodulatory effects of green soybean extracts
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DOI：
10.1016/j.foodchem.2012.12.014
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发表时间：
2013-06-15
期刊：
影响因子：
8.8
通讯作者：
Imai, Shinjiro
中科院分区：
文献类型：
--
作者：
Katayanagi, Yuki;Yasui, Kensuke;Imai, Shinjiro
本研究旨在探讨绿色大豆（Glycine max）提取物对2，4-甲苯二异氰酸酯（TDI）诱导的豚鼠鼻炎模型和人体过敏性鼻炎的免疫调节活性。根据绿色大豆的热水提取物调节小鼠脾细胞中TNF家族的B细胞活化因子和增殖诱导配体的产生的能力，选择其用于动物实验。绿色大豆提取物显著降低小鼠卵清蛋白（OVA）特异性IgE水平，并显著抑制TDI诱导的鼻粘膜分泌。使用日本雪松花粉症对16名受试者进行了一项开放标签的人类初步研究。日本柳杉花粉症的症状评分在长期绿色大豆提取物摄入组中优于短期摄入组。绿色大豆提取物作为口服活性免疫调节剂用于治疗各种过敏性疾病具有很大的潜力。(C)2012爱思唯尔有限公司保留所有权利。
The present study was performed to investigate the immune-modulating activities of extracts from green soybean (Glycine max) in a 2,4-toluene diisocyanate (TDI)-inducing guinea pig rhinitis model and a human trial study for allergic rhinitis. Hot water extracts of green soybean were chosen for animal experimentation on the basis of their ability to regulate the production of B cell-activating factor of the TNF family and a proliferation-inducing ligand in mouse spleen cells. Green soybean extracts significantly decreased the levels of ovalubumin (OVA)-specific IgE in mice and significantly suppressed the TDI-induced nasal mucosa secretion. An open-label human pilot study was performed on 16 subjects, using Japanese cedar pollinosis. The symptom scores for Japanese cedar pollinosis were better in the long-term green soybean extracts intake group than in the withdrawal short-term intake group. Green soybean extracts had great potential as an orally active immune modulator for the treatment of various allergic diseases. (C) 2012 Elsevier Ltd. All rights reserved.