The relationship between cognitive function and high-resolution diffusion tensor MRI of the cingulum bundle in multiple sclerosis.
The relationship between cognitive function and high-resolution diffusion tensor MRI of the cingulum bundle in multiple sclerosis.
复制标题
多发性硬化症患者认知功能与蝶鞍束高分辨率弥散张量核磁共振成像之间的关系。
DOI：
10.1177/1352458515576983
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Phillips MD
中科院分区：
文献类型：
--
作者：
Koenig KA;Sakaie KE;Lowe MJ;Lin J;Stone L;Bermel RA;Beall EB;Rao SM;Trapp BD;Phillips MD
影像学可以提供与行为和认知症状相关的多发性硬化症疾病进展的非侵入性神经标志物。过去的工作表明，扩散张量成像（DTI）提供了一个衡量白色物质病理，包括脱髓鞘和轴突计数。在目前的研究中，作者调查了扣带束中DTI测量与MS常见缺陷的关系，包括情景记忆，工作记忆和信息处理速度。57名MS患者和17名年龄和教育程度匹配的对照组接受了高空间分辨率弥散扫描和认知测试。概率追踪用于产生从后扣带皮层到内嗅皮层的轨迹。径向和轴向扩散率值在患者和对照组之间存在显著差异（p<0.031），并且在患者中，双侧扩散测量值与情景记忆和处理速度的测量值显著相关（p<0.033）。本文报告的基于纤维束成像的后扣带完整性测量支持进一步发展DTI作为MS患者轴突完整性和认知功能的可行测量。
Imaging can provide noninvasive neural markers of disease progression in multiple sclerosis that are related to behavioral and cognitive symptoms. Past work suggests that diffusion tensor imaging (DTI) provides a measure of white matter pathology, including demyelination and axonal counts. In the current study, the authors investigate the relationship of DTI measures in the cingulum bundle to common deficits in MS, including episodic memory, working memory, and information processing speed. Fifty-seven patients with MS and 17 age- and education-matched controls underwent high-spatial resolution diffusion scans and cognitive testing. Probabilistic tracking was used to generate tracks from the posterior cingulate cortex to the entorhinal cortex. Radial and axial diffusivity values were significantly different between patients and controls (p<0.031), and in patients bilateral diffusion measures were significantly related to measures of episodic memory and speed of processing (p<0.033). The tractography-based measures of posterior cingulum integrity reported here support further development of DTI as a viable measure of axonal integrity and cognitive function in patients with MS.