Photocatalytic coupling of amines to imidazoles using a Mo–ZnIn2S4 catalyst
Photocatalytic coupling of amines to imidazoles using a Mo–ZnIn2S4 catalyst
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DOI：
10.1039/c7gc01728f
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发表时间：
2017-10
期刊：
影响因子：
9.8
通讯作者：
Min Wang;L. Lihua;Jianmin Lu;Nengchao Luo;Zhang Xiaochen;Feng Wang
中科院分区：
文献类型：
--
作者：
Min Wang;L. Lihua;Jianmin Lu;Nengchao Luo;Zhang Xiaochen;Feng Wang
取代的咪唑传统上通过多种原料的共缩合来合成。在此，我们报道了一种在室温下通过容易获得的胺的光环合来合成取代咪唑的新路线。该反应是通过可见光诱导的C-C/C-N键偶联和随后的脱氢反应在Mo-ZnIn 2S 4作为多相光催化剂上实现的。一个广泛的胺转化为相应的三-和四-取代的咪唑与高达96%的总收率。该反应具有简单、高效、条件温和等优点，可用于合成转化。
Substituted imidazoles are traditionally synthesized by co-condensation of multiple feedstocks. Herein, we report a new route for the synthesis of substituted imidazoles via photocyclization of readily available amines at room temperature. The reaction is achieved by the visible-light-induced C–C/C–N bond coupling and subsequent dehydrogenation reaction over Mo–ZnIn2S4 as a heterogeneous photocatalyst. A wide range of amines were converted into the corresponding tri- and tetra-substituted imidazoles with up to 96% total yields. The simplicity, high efficiency and mild condition merits of this new reaction will enable it to be useful in synthetic transformations.