Genome-wide signatures of male-mediated migration shaping the Indian gene pool
Genome-wide signatures of male-mediated migration shaping the Indian gene pool
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DOI：
10.1038/jhg.2015.51
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发表时间：
2015-09-01
影响因子：
3.5
通讯作者：
Pitchappan, Ramasamy
中科院分区：
文献类型：
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作者：
ArunKumar, GaneshPrasad;Tatarinova, Tatiana V.;Pitchappan, Ramasamy
有关文化和人口因素在人类地理扩散过程中的贡献的多个问题在很大程度上仍未得到解答。印度是一个早期人类定居的土地以及由此产生的多样性，是寻找一些答案的好地方。在这项研究中，我们利用 GenoChip 对 78 名男性进行了基因分型，探索了印度的遗传结构。他们的全基因组单核苷酸多态性（SNP）多样性在影响印度基因库的各种协变量的背景下进行了检查。全基因组 SNP 数据的混合分析显示，所有印度样本中西南亚成分的比例很高。基于混合比例的层次聚类揭示了与地理和语言归属相关的七个不同的聚类。全基因组 SNP 主成分分析中 Y 染色体单倍群的凸包重叠显示出 F-star-M89、H-star-M69、L1-M27、O2a-M95 和 O3a3c1-M117 的明显非重叠多边形，表明印度基因库的男性介导的迁移和扩张。与线粒体 DNA 分支缺乏相似的相关性表明女性具有共同的遗传祖先。我们认为，古代男性介导的迁徙事件和在不同地区的定居导致了今天的印度情景和人口。
Multiple questions relating to contributions of cultural and demographical factors in the process of human geographical dispersal remain largely unanswered. India, a land of early human settlement and the resulting diversity is a good place to look for some of the answers. In this study, we explored the genetic structure of India using a diverse panel of 78 males genotyped using the GenoChip. Their genome-wide single-nucleotide polymorphism (SNP) diversity was examined in the context of various covariates that influence Indian gene pool. Admixture analysis of genome-wide SNP data showed high proportion of the Southwest Asian component in all of the Indian samples. Hierarchical clustering based on admixture proportions revealed seven distinct clusters correlating to geographical and linguistic affiliations. Convex hull overlay of Y-chromosomal haplogroups on the genome-wide SNP principal component analysis brought out distinct non-overlapping polygons of F-star-M89, H-star-M69, L1-M27, O2a-M95 and O3a3c1-M117, suggesting a male-mediated migration and expansion of the Indian gene pool. Lack of similar correlation with mitochondrial DNA clades indicated a shared genetic ancestry of females. We suggest that ancient male-mediated migratory events and settlement in various regional niches led to the present day scenario and peopling of India.