Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight.
Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight.
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长期 CCK-瘦素协同作用表明 CCK 在体重调节中发挥作用。
DOI：
10.1152/ajpregu.1999.276.4.r1038
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Ritter,RC
中科院分区：
文献类型：
--
作者：
Matson,CA;Ritter,RC
肠道肽CCK是一种营养相关信号，对控制食物摄入很重要。在目前的研究中，我们观察到在侧脑室注射瘦素（2-5 μg）后2-3小时单次腹腔注射CCK（1-2 μg/kg）在随后的48小时内比单独注射瘦素更能减少体重和食物摄入。单独CCK对48小时食物摄入量或体重没有影响，但在30分钟蔗糖试验中显著减少了摄食。然而，减少30分钟的蔗糖摄入量CCK没有增强先前脑室内瘦素。目前的数据表明，CCK可以有助于调节体重时，中枢瘦素水平升高。
The gut peptide CCK is a nutrient-related signal important to the control of food intake. In the present studies, we observed that a single intraperitoneal injection of CCK (1–2 μg/kg) given 2–3 h after intracerebroventricular leptin (2–5 μg) reduced body weight and chow intake over the ensuing 48 h more than did leptin alone. CCK alone had no effect on either 48-h chow intake or body weight but significantly reduced feeding during a 30-min sucrose test. However, reduction of 30-min sucrose intake by CCK was not enhanced by prior intracerebroventricular leptin. The present data suggest that CCK can contribute to the regulation of body weight when central leptin levels are elevated.