A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.

A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.
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DOI:
10.1093/bioinformatics/btp121
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发表时间:
2009-05-01
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
通讯作者:
Moslehi R
Moslehi R
中科院分区:
其他
文献类型:
--
作者:
Kuznetsov IB;McDuffie M;Moslehi R

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摘要:N-乙酰基转移酶-2(NAT2)是催化芳香族和杂环胺类致癌物乙酰化的重要酶。人类群体中的个体被分为三种NAT2乙酰化表型:慢型、快型和中间型。Nat2PRED是一种网络服务器,它实现了一种有监督的模式识别方法,从在Nat2基因282、341、481、590、803和857位发现的SNP中推断出Nat2的表型。该网络服务器可用于快速确定遗传屏幕中的NAT2表型。Http://nat2pred.rit.albany.edu联系方式:ikuznetsov@albany.edu;
Summary:N-acetyltransferase-2 (NAT2) is an important enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server can be used for a fast determination of NAT2 phenotypes in genetic screens. Availability:Freely available at http://nat2pred.rit.albany.edu Contact:ikuznetsov@albany.edu; rmoslehi@albany.edu Supplementary information:Supplementary data are available at Bioinformatics online.
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