Induction of laurate omega-hydroxylase by di (2-ethylhexyl)phthalate in rat liver microsomes.
Induction of laurate omega-hydroxylase by di (2-ethylhexyl)phthalate in rat liver microsomes.
复制标题
邻苯二甲酸二（2-乙基己基）酯在大鼠肝微粒体中诱导月桂酸 omega-羟化酶。
DOI：
10.1016/0006-291x(84)90723-x
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发表时间：
1984
影响因子：
3.1
通讯作者：
Chance,C
中科院分区：
文献类型：
--
作者：
Okita,R;Chance,C
Liver microsomes, prepared from rats fed a diet containing di (2-ethylhexyl) phthalate, were observed to hydroxylate lauric acid at carbon 12 at a specific activity 6 times greater than control rats. There was no increase in the specific activity of the laurate 11-hydroxylase. The specific activity of hepatic microsomal NADPH-cytochrome c reductase was increased 2-fold by phthalate feeding, but no effect was observed in the specific contents of cytochromes b 5 or P-450. These results indicate that di (2-ethylhexyl) phthalate is similar to the hypolipidemic agent and peroxisomal proliferator, clofibrate, which was previously reported to be a novel inducer of the cytochrome P-450 mediated ω-hydroxylation of fatty acids.
