Maternal immunization promotes the immune response of neonates towards hepatitis B vaccine
Maternal immunization promotes the immune response of neonates towards hepatitis B vaccine
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孕产妇免疫促进新生儿对乙型肝炎疫苗的免疫反应
DOI：
10.1111/jvh.12103
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发表时间：
2013-12-01
影响因子：
2.5
通讯作者：
Shao, Z.
中科院分区：
文献类型：
--
作者：
Zhang, W.;Guo, Z.;Shao, Z.
感染B型肝炎病毒（HBV）的婴儿面临发展严重并发症的风险。不幸的是，尽管有普遍的疫苗接种计划，5%或更多的接种疫苗的新生儿仍然没有达到抗B型肝炎病毒表面抗原滴度（抗-HBs）的保护水平。本研究的目的是使用动物实验和基于人群的研究，以确定是否母亲接种乙肝疫苗影响新生儿接种疫苗的结果。本研究使用6头母猪和53头新生仔猪，并随机分配至疫苗接种组（3个20 g剂量的重组HBV疫苗）。所有仔猪均随访至10周龄，抽取外周血检测抗-HBs。另外，还对449名有婴儿的母亲进行了横断面研究。采用结构式问卷调查收集人口学、医学和母亲资料，并采集外周血进行抗-HBs检测。动物实验结果表明，免疫母猪所生的未免疫仔猪和未免疫母猪所生的未免疫仔猪抗-HBs均为阴性。重复测量方差分析表明，免疫母猪所产免疫仔猪的抗-HBs滴度显著高于未免疫母猪所产免疫仔猪（P
Infants infected with hepatitis B virus (HBV) face the risk of developing severe complications. Unfortunately, in spite of universal vaccination programmes, 5% or more of vaccinated newborns still do not achieve protective levels of anti-hepatitis B virus surface antigen titres (anti-HBs). The aim of this study was to use animal experiments and population-based research to determine whether maternal vaccination against HBV affects the outcome of neonatal vaccination. Six sows and 53 newborn piglets were used for this study and randomly assigned to the vaccination group (three 20g doses of recombinant HBV vaccine). All the piglets were followed up to 10weeks of age, and peripheral blood was withdrawn for measurement of anti-HBs. A cross-sectional study was also conducted on 449 mothers with infants. A structured questionnaire was used to collect demographic, medical and maternal data, and their peripheral blood was collected for measurement of anti-HBs. The results of animal experiments demonstrated that nonvaccinated piglets born to vaccinated sows and nonvaccinated piglets born to nonvaccinated sows were negative for anti-HBs. Repeated measures analysis of variance showed that the titres of anti-HBs in vaccinated piglets born to vaccinated sows were significantly higher than in vaccinated piglets born to nonvaccinated sows (P