Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair.
Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair.
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DOI：
10.3389/fnhum.2015.00586
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发表时间：
2015
影响因子：
2.9
通讯作者：
Tan S
中科院分区：
文献类型：
--
作者：
Huang Y;Li Y;Chen J;Zhou H;Tan S
研究人员热情地关注神经干细胞（NSC）治疗各种疾病，包括中风，神经退行性疾病，脊髓损伤和抑郁症。虽然大量的证据表明，神经行为的改善可能受益于神经干细胞支持再生的动物模型，方法内源性和移植的神经干细胞的迁移，增殖，成熟和整合的神经干细胞的障碍。电刺激（ES）可能是一种选择性的非药物方法动员神经干细胞在中枢神经系统。该技术适用于临床应用，因为它是成熟的，其潜在的并发症是可控的。在这里，我们提供了一个全面的审查新兴的积极作用，不同的电线索在调节神经干细胞的生物学在体外和体内，以及生物材料为基础的和化学刺激的神经干细胞。在未来，ES结合干细胞治疗或其他线索可能成为促进脑修复的方法。
Researchers are enthusiastically concerned about neural stem cell (NSC) therapy in a wide array of diseases, including stroke, neurodegenerative disease, spinal cord injury, and depression. Although enormous evidences have demonstrated that neurobehavioral improvement may benefit from NSC-supporting regeneration in animal models, approaches to endogenous and transplanted NSCs are blocked by hurdles of migration, proliferation, maturation, and integration of NSCs. Electrical stimulation (ES) may be a selective non-drug approach for mobilizing NSCs in the central nervous system. This technique is suitable for clinical application, because it is well established and its potential complications are manageable. Here, we provide a comprehensive review of the emerging positive role of different electrical cues in regulating NSC biology in vitro and in vivo, as well as biomaterial-based and chemical stimulation of NSCs. In the future, ES combined with stem cell therapy or other cues probably becomes an approach for promoting brain repair.