Chiral lithium binaphtholate aqua complex as a highly effective asymmetric catalyst for cyanohydrin synthesis
Chiral lithium binaphtholate aqua complex as a highly effective asymmetric catalyst for cyanohydrin synthesis
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DOI：
10.1021/ja051125c
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发表时间：
2005-08-10
影响因子：
15
通讯作者：
Ishihara, K
中科院分区：
文献类型：
--
作者：
Hatano, M;Ikeno, T;Ishihara, K
已经开发出一种使用手性联萘酸锂水合物或醇络合物与芳香醛进行高度对映选择性氰醇合成的方法，并且是一种简单且廉价的催化剂，适用于成功生产克级氰醇的工艺化学。对映体过量的显着改进已经实现，同时氰醇产品的绝对立体化学相对于彻底“干燥”的催化系统也发生了有趣的转变。
A highly enantioselective cyanohydrin synthesis with aromatic aldehydes using chiral lithium binaphtholate aqua or alcohol complexes has been developed and is a simple and inexpensive catalyst suitable for process chemistry to give gram-scale cyanohydrins successfully. Dramatic improvements in enantiomeric excess have been realized along with an interesting changeover in absolute stereochemistry of cyanohydrin product against the thoroughly “dry” catalytic systems.