Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study
Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study
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DOI：
10.1177/1352458510365156
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发表时间：
2010-07-01
影响因子：
5.8
通讯作者：
Paul, Friedemann
中科院分区：
文献类型：
--
作者：
Bock, Markus;Brandt, Alexander Ulrich;Paul, Friedemann
传统的时域光学相干断层扫描已经建立了在体内评估视网膜轴突损失的多发性硬化症。创新的谱域成像在数据采集速度、分辨率和再现性方面上级传统技术。然而，到目前为止，这两种技术的可比性尚未在多发性硬化症中进行研究。在这项涉及55名多发性硬化症患者的研究中，使用两种技术（Stratus时域光学相干断层扫描和Cirrus谱域光学相干断层扫描，Carl Zeiss Meditec）获得的数据显示出良好的相关性（Pearson r=0.926，p < 0.001）。然而，由于绝对视网膜神经纤维层测量值存在相当大的差异（平均值+/-标准差8.1 μ m +/- 6.2，范围-12至23 μ m），两种器械的结果不可互换。
Conventional time domain optical coherence tomography has been established for the in vivo assessment of retinal axonal loss in multiple sclerosis. The innovative spectral domain imaging is superior to the conventional technique with respect to data acquisition speed, resolution and reproducibility. However, until now comparability of the two techniques has not been investigated in multiple sclerosis. In this study involving 55 multiple sclerosis patients, data obtained using both techniques (Stratus time domain optical coherence tomography and Cirrus spectral domain optical coherence tomography, Carl Zeiss Meditec) showed an excellent correlation (Pearson's r=0.926, p < 0.001). However, owing to considerable differences in absolute retinal nerve fibre layer measurements (mean +/- standard deviation 8.1 mu m +/- 6.2, range -12 to 23 mu m), results from the two devices are not interchangeable.